Sci Transl Med:科研人员研发出流感预报工具

2017-11-03 林小春 新华社

这项研究结果发表在新一期美国《科学·转化医学》杂志上。目前,在芝加哥大学做研究的论文第一作者杜向军告诉新华社记者,流感病毒变化快,变化后的病毒传播或感染能力不同,这使得每年的流感情况都很难提前准确预报。而他们在流行病学群体模型中加入流感病毒进化的变化信息,每年6月根据收集的流感病毒序列数据以及来自监测部门的流行病学数据,就能预测未来一年流感感染动态与人数。

又到北半球秋冬流感高发季,接下来的主要流感类型是什么?又有多少人感染?美国芝加哥大学开发的一种类似天气预报的新工具,也许能提前给我们一些答案。研究人员利用这个工具做出预测,在美国,这个流感季将是甲型H3N2流感的高发季。

这项研究结果发表在新一期美国《科学·转化医学》杂志上。目前,在芝加哥大学做研究的论文第一作者杜向军告诉新华社记者,流感病毒变化快,变化后的病毒传播或感染能力不同,这使得每年的流感情况都很难提前准确预报。而他们在流行病学群体模型中加入流感病毒进化的变化信息,每年6月根据收集的流感病毒序列数据以及来自监测部门的流行病学数据,就能预测未来一年流感感染动态与人数。

“整个过程类似于天气预报,”杜向军说。“我们的工作是去年完成的,当时对过去一个流感季完全不了解。现在有了数据,我们发现我们的预测是正确的。”

此外,研究人员测试了这个工具在2003年至2011年期间的预测能力,并根据这些数据模型逐年预测2011年至2016年的每个流感季,结果显示所预测的每年流感总感染人数与观测数据相近。

杜向军说,以前的流感预测模型分两个方向:一个单纯预测流感病毒的进化情况,已能做到对未来一年的长期预测,但不能预测感染人数;另一个单纯进行群体动态预测,能预测感染人数,但只对未来很短时间,比如两周的预测比较准确。前者没有利用人群免疫状况信息,后者没有利用进化信息。

“我们的模型把两者结合起来,因此能预测未来一年的流感感染人数。这个信息具有重要的现实意义,可让我们有充足的时间做准备,调配资源,推广疫苗,更好地降低流感对民众健康的影响,”他说,“当然我们的方法不可能完全超越或取代现有方法,但它是非常好的补充。”

杜向军说,这个模型只针对美国,但现在也在与中国国家流感中心合作开展中国模型的研究。

原始出处:

Du X,et al. Evolution-informed forecasting of seasonal influenza A (H3N2).Sci Transl Med. 2017 Oct 25;9(413). pii: eaan5325.

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    2018-03-14 bsmagic9140
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    2017-11-05 lqvr
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    2017-11-03 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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