SCI REP:中性粒细胞与淋巴细胞比变化值是一个更好的胃癌患者生存预测指标!

2017-10-25 xing.T MedSci原创

由此可见,在预测胃癌患者生存率方面,相比于iNLR,NLRc可能是一个更好的指标。

术后中性粒细胞与淋巴细胞比值的变化(NLRc)反映了治疗后的炎症反应和免疫反应之间平衡的动态变化。据文献报道在胃癌患者中,较高的初始NLR(iNLR)是胃癌患者的一个预后指标,但是在胃癌患者中NLRc的临床意义仍不清楚。近日,Scientific reports 杂志上针对这一问题发表了一篇研究文章。

研究人员评估了734例接受全胃/胃大部切除术以及内镜黏膜下剥离术治疗胃腺癌患者的NLRc。这些受试者分别在诊断胃癌10天内和手术后3-6个月内记录了iNLR和NLRc。研究人员使用受试者工作特征(ROC)曲线评估了iNLR 或NLRc与患者生存率之间的相关性。

分析结果显示相比于iNLR,NLRc对胃癌患者的生存率有较高的预测能力。NLRc被定义为负(低于iNLR)和正(高于iNLR)。研究人员发现在晚期AJCC、局部复发、远处转移、神经浸润并辅助化疗的患者中经常可以观察到正NLRc(所有P<0.05)。单因素和多因素分析显示患者的生存率和NLRc之间存在显著的相关性(所有P<0.05),但iNLR与生存率之间没有存在相关性。

由此可见,在预测胃癌患者生存率方面,相比于iNLR,NLRc可能是一个更好的指标。

原始出处:


Kyueng-Whan Min,et al. Persistent elevation of postoperative neutrophil-to-lymphocyte ratio: A better predictor of survival in gastric cancer than elevated preoperative neutrophil-to-lymphocyte ratio.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-13969-x

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    2017-10-30 天涯183

    非常好的文章.学习了

    0

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    2017-10-26 thlabcde

    好自恋好资料学习了!

    0