CHEST:女性较男性的另一优势!

2017-03-18 MedSci MedSci原创

纵向研究的证据报道了阻塞性睡眠呼吸暂停(OSA)和高血压之间相关性的矛盾结果。此前对Vitoria睡眠队列的分析中,有研究评估了OSA与发生高血压的风险之间的关系,并且在调整混杂因素后没有发现两者之间存在独立的关联。近期,一项发表在杂志CHEST上的研究进行进一步分析,以评估基于性别差异的OSA与2级高血压(收缩压≥160 mmHg和/或舒张压≥100 mmHg)之间的关系。此项研究对中年一般人群

纵向研究的证据报道了阻塞性睡眠呼吸暂停(OSA)和高血压之间相关性的矛盾结果。


此前对Vitoria睡眠队列的分析中,有研究评估了OSA与发生高血压的风险之间的关系,并且在调整混杂因素后没有发现两者之间存在独立的关联。

近期,一项发表在杂志CHEST上的研究进行进一步分析,以评估基于性别差异的OSA与2级高血压(收缩压≥160 mmHg和/或舒张压≥100 mmHg)之间的关系。

此项研究对中年一般人群进行为期7.5±0.8年的前瞻性研究,其中包括1,155名正常血压受试者(43.7%的男性)。对受试人群进行血压测量(在基线和随访时),并在基线时进行生理记录。使用逻辑回归模型来确定呼吸性干扰指数(RDI)和2期高血压之间的关联,并且使用递归分割法来确定与2期高血压发病率相关的变量。将RDI分为亚组(0-2.9,3-6.9,7-13.9和≥14),使用第一个亚组作为参考。

此项研究结果显示:对于男性,RDI≥14与2期高血压的OR增加显着相关(OR = 2.54(95%CI 1.09-5.95),p = 0.032]。这种关联在女性中没有统计学显着意义(p = 0.371)。

此项研究结果表明:在男性中,中度至严重OSA与更严重的高血压发病率相关,但在女性中没有相关性。

原始出处:
Cano-Pumarega I, Barbé F, et al. Sleep Apnea and Hypertension: Are there gender differences? The Vitoria Sleep Cohort. Chest. 2017 Mar 11. pii: S0012-3692(17)30369-0. doi: 10.1016/j.chest.2017.03.008. 

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    2017-08-30 Smile2680
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    2017-03-21 喜婷

    学习了

    0

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    2017-03-19 喜婷

    学习了

    0

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    2017-03-18 医艺依意

    这样也行,好吧

    0

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    2017-03-18 1e1a50a1m36(暂无匿称)

    中度至严重OSA与更严重的高血压发病率相关,但在女性中没有相关性。

    0

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    2017-03-18 Albert Wu

    在男性中,中度至严重OSA与更严重的高血压发病率相关,但在女性中没有相关性。

    0

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