Nat Genet:全基因组关联研究(GWAS)发现6q22位置与前列腺癌风险有关

2014-01-19 MedSci MedSci原创

   来自芬兰、瑞典和中国的一个研究团队,在2014年1月份的《自然遗传学》(Nature Genetics)上发表的一项研究中,发现了与一种转录因子相关的前列腺癌风险影响机制,这种转录因子能够更强地结合到一个特殊的SNP变异上,从而启动一种遗传学程序,增强前列腺癌的增生和转移。这项研究由芬兰科学院资助,为探究SNP变异如何引起前列腺癌风险提高和其它人类疾病的相关机制,开辟了一个重要的新方向。

   来自芬兰、瑞典和中国的一个研究团队,在2014年1月份的《自然遗传学》(Nature Genetics)上发表的一项研究中,发现了与一种转录因子相关的前列腺癌风险影响机制,这种转录因子能够更强地结合到一个特殊的SNP变异上,从而启动一种遗传学程序,增强前列腺癌的增生和转移。这项研究由芬兰科学院资助,为探究SNP变异如何引起前列腺癌风险提高和其它人类疾病的相关机制,开辟了一个重要的新方向。
前列腺癌是最常被诊断的恶性肿瘤,是全球男性癌症相关死亡的第二大最常见原因。在芬兰,每年有超过4000例前列腺癌新病例被确诊。
人类基因组,在全世界人口中大体上是相同的。然而,人和人之间,在一个单核苷酸上,通常存在数以百万计的小变异或多态性,这些变异被称为SNP(单核苷酸多态性,single nucleotide polymorphisms)。目前,研究人员利用全基因组关联研究(genome-wide association studies),已经确定了数以千计的与各种疾病易感性相关的SNPs。然而,这些SNPs的作用机理仍不明确,特别是非编码区的多态性。
在这项研究中,研究人员采用来自数以万计的前列腺癌患者和健康人DNA样本,和全基因组关联研究,发现了与前列腺癌风险相关的几十个SNPs。研究人员在功能性HOXB13结合位点中发现了前列腺癌风险相关的SNP rs339331 (6q22)。SNP rs339331上的风险相关T等位基因,能够增强HOXB13与一个转录增强子的结合,使rs339331相关基因RFX6出现等位基因特异性上调。抑制RFX6,能够减少前列腺癌细胞的增生、迁移和入侵。临床数据表明,RFX6基因在人类前列腺癌中的上调,与肿瘤进展、转移和生化复发风险有关。最后,研究人员还观察到,rs339331的风险相关T基因,与人类前列腺肿瘤中的RFX6 mRNA水平增加存在一个密切的联系。总之,这项研究表明,rs339331,通过与前列腺癌易感基因HOXB13之间的功能性相互作用,改变RFX6的表达,进而影响前列腺癌风险。
然而,因为这些SNPs中的大多数,并没有在基因组的蛋白编码区被发现,所以很难找到引起前列腺癌风险的基因。因此,这些单核苷酸遗传变异或SNPs是如何引起前列腺癌风险的,这个问题尚未得到解答。
这项国际性多学科研究,是由芬兰奥卢大学的青年研究员Gonghong Wei带领,科研团队成员来自几所大学和研究机构。包括芬兰的三所高校(奥卢大学、坦佩雷大学和赫尔辛基大学),瑞典卡罗林斯卡医学院,中国复旦大学泌尿外科研究所的徐剑锋教授也合作参与了这项研究。

原始出处:
Huang Q, Whitington T, Gao P, Lindberg JF, Yang Y, Sun J, Väisänen MR, Szulkin R, Annala M, Yan J, Egevad LA, Zhang K, Lin R, Jolma A, Nykter M, Manninen A, Wiklund F, Vaarala MH, Visakorpi T, Xu J, Taipale J, Wei GH.A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding.Nat Genet. 2014 Jan 5. doi: 10.1038/ng.2862.

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    2014-09-15 cy0324
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    2014-08-13 liye789132251
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21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
    2014-10-04 sjq027
  4. [GetPortalCommentsPageByObjectIdResponse(id=2048563, encodeId=29382048563d1, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Sep 15 07:16:00 CST 2014, time=2014-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879872, encodeId=f55118e987232, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, 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21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2048563, encodeId=29382048563d1, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Sep 15 07:16:00 CST 2014, time=2014-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879872, encodeId=f55118e987232, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, 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21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2048563, encodeId=29382048563d1, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Sep 15 07:16:00 CST 2014, time=2014-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879872, encodeId=f55118e987232, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, content=<a href='/topic/show?id=62eb2939954' target=_blank style='color:#2F92EE;'>#全基因组关联研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29399, encryptionId=62eb2939954, topicName=全基因组关联研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546431, encodeId=39271546431b6, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
    2014-02-03 canlab
  7. [GetPortalCommentsPageByObjectIdResponse(id=2048563, encodeId=29382048563d1, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Sep 15 07:16:00 CST 2014, time=2014-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879872, encodeId=f55118e987232, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Aug 13 05:16:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061416, encodeId=20902061416cc, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Oct 04 01:16:00 CST 2014, time=2014-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685926, encodeId=96c316859262a, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri May 16 14:16:00 CST 2014, time=2014-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022542, encodeId=5c842022542d0, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Fri Sep 12 07:16:00 CST 2014, time=2014-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733670, encodeId=ead91e3367055, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, content=<a href='/topic/show?id=62eb2939954' target=_blank style='color:#2F92EE;'>#全基因组关联研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29399, encryptionId=62eb2939954, topicName=全基因组关联研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546431, encodeId=39271546431b6, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
    2014-01-21 lxg951
  8. [GetPortalCommentsPageByObjectIdResponse(id=2048563, encodeId=29382048563d1, content=<a href='/topic/show?id=4363e929ad' target=_blank style='color:#2F92EE;'>#Gene#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7929, encryptionId=4363e929ad, topicName=Gene)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=63a4277, createdName=cy0324, createdTime=Mon Sep 15 07:16:00 CST 2014, time=2014-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1879872, encodeId=f55118e987232, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Aug 13 05:16:00 CST 2014, time=2014-08-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061416, encodeId=20902061416cc, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d58a435, createdName=sjq027, createdTime=Sat Oct 04 01:16:00 CST 2014, time=2014-10-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685926, encodeId=96c316859262a, content=<a href='/topic/show?id=66f3e93862' target=_blank style='color:#2F92EE;'>#Genet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7938, encryptionId=66f3e93862, topicName=Genet)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d3e128296421, createdName=江川靖瑶, createdTime=Fri May 16 14:16:00 CST 2014, time=2014-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022542, encodeId=5c842022542d0, content=<a href='/topic/show?id=42b532553af' target=_blank style='color:#2F92EE;'>#前列腺癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32553, encryptionId=42b532553af, topicName=前列腺癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f42500210, createdName=12498ef1m31(暂无昵称), createdTime=Fri Sep 12 07:16:00 CST 2014, time=2014-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1733670, encodeId=ead91e3367055, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, 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21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
  9. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, content=<a href='/topic/show?id=62eb2939954' target=_blank style='color:#2F92EE;'>#全基因组关联研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29399, encryptionId=62eb2939954, topicName=全基因组关联研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546431, encodeId=39271546431b6, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Tue Jan 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  10. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12668, encryptionId=d4f412668a4, topicName=NET)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7ea033781210, createdName=canlab, createdTime=Mon Feb 03 00:16:00 CST 2014, time=2014-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1280028, encodeId=d9341280028d6, content=<a href='/topic/show?id=b05983454a' target=_blank style='color:#2F92EE;'>#GWAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8345, encryptionId=b05983454a, topicName=GWAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342206, encodeId=9acb134220637, content=<a href='/topic/show?id=62eb2939954' target=_blank style='color:#2F92EE;'>#全基因组关联研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29399, encryptionId=62eb2939954, topicName=全基因组关联研究)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=636e2500187, createdName=12498da4m32(暂无昵称), createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546431, encodeId=39271546431b6, content=<a href='/topic/show?id=81eb2939373' target=_blank style='color:#2F92EE;'>#全基因组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29393, encryptionId=81eb2939373, topicName=全基因组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc2113925052, createdName=ms1692810954239974, createdTime=Tue Jan 21 13:16:00 CST 2014, time=2014-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6900, encodeId=13eb69000d, content=GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Mon Jan 20 09:08:00 CST 2014, time=2014-01-20, status=1, ipAttribution=)]
    2014-01-20 lovetcm

    GWAS就是烧钱的玩意儿,做了结果呢?几乎没有实际指导意义的

    0

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