Blood:抗体在移植物抗宿主病的发生过程中的作用。

2017-11-15 MedSci MedSci原创

同种异体造血干细胞移植(HSCT)后发生慢性移植物抗宿主病(cGVHD),是一种复杂的免疫反应,可导致多种组织慢性损伤。既往研究提示,供体B细胞及其产生的抗体在cGVHD的发生过程中发挥重要作用。为探究抗体在cGVHD中的病理作用,研究人员聚焦于移植后产生的靶向在多种cGVHD影响的组织中表达的细胞表面抗原的IgG抗体,IgG抗体具有潜在的影响体内活细胞的特性。以血小板结合的细胞膜蛋白为靶点,研究

同种异体造血干细胞移植(HSCT)后发生慢性移植物抗宿主病(cGVHD),是一种复杂的免疫反应,可导致多种组织慢性损伤。既往研究提示,供体B细胞及其产生的抗体在cGVHD的发生过程中发挥重要作用。

为探究抗体在cGVHD中的病理作用,研究人员聚焦于移植后产生的靶向在多种cGVHD影响的组织中表达的细胞表面抗原的IgG抗体,IgG抗体具有潜在的影响体内活细胞的特性。

以血小板结合的细胞膜蛋白为靶点,研究人员发现,与未发生cGVHD的患者和健康捐献者相比,发生cGVHD的患者的膜抗原相关的抗体表达水平显着升高。与临床诊断cGVHD前相比,血浆反应性抗体水平也显着增加,而且随着cGVHD治疗(强的松、IL-2或利妥昔单抗)而又减少。

通过免疫沉淀和质谱分析,研究人员鉴定出43个抗体靶向的膜蛋白,cGVHD患者的血浆中的抗体特异性的靶向其中6个蛋白。与未发生cGVHD的患者和健康捐献者相比,cGVHD患者的抗体与上术6种抗原的相互作用更突出。

上术结果表明cGVHD患者多产生靶向活细胞的细胞膜抗原的抗体,进一步支持B细胞及抗体在cGVHD的发生过程中发挥作用这一理论。

原始出处:

Kathy S. Wang, et al.Antibodies Targeting Surface Membrane Antigens in Patients with Chronic Graft-Versus-Host Disease.Blood  2017  :blood-2017-08-801001;  doi: https://doi.org/10.1182/blood-2017-08-801001

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    2017-12-17 xuyong535
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    2017-11-17 wincls
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    2017-11-16 天涯183

    非常好的文章.学习了

    0

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    2017-11-15 清风拂面

    谢谢分享.学习了

    0

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    2017-11-15 1e1b8538m79(暂无匿称)

    不错的文章值得推荐

    0

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Incyte制药公司近日宣布,美国食品和药物管理局(FDA)已授予Jakavi(ruxolitinib,鲁索替尼)治疗急性移植物抗宿主病(graft-versus-host disease,GVHD)的突破性药物资格(BTD)。移植物抗宿主病(GVHD)是由于移植物的抗宿主反应而引起的一种免疫性疾病,是异基因造血干细胞移植的主要并发症和造成死亡的主要原因。GVHD患者最常见的受累器官为皮肤、胃

Sci Transl Med:重大发现!新研究发现或可有效预防移植物抗宿主病的发生

Sci Transl Med:重大发现!新研究发现或可有效预防移植物抗宿主病的发生来自西雅图儿研所实验室的研究人员发现,使用现有药物可靶向移植物抗宿主病(GVHD)发生的遗传途径,GVHD是骨髓移植常见的也是致命的并发症,该研究成果在线发表于Science Translational Medicine。发生GVHD的患者,骨髓移植来源的T细胞可攻击移植受体。在美国每年有1万多名患者接受骨髓移植来治

Blood:利妥昔单抗为基础的一线疗法对allo-SCT后cGVHD的效果。

慢性移植物抗宿主病(cGVHD)是异体干细胞移植(allo-SCT)后非复发性死亡和发病的主要原因。为提高这类患者的预后,Florent Malard及其同事进行一前瞻性、多中心的2期临床试验,评估糖皮质激素联合环孢霉素A中加入利妥昔单抗作为新诊断的allo-SCT后cGVHD一线疗法的效果。

Lancet Haematol:间充质干细胞治疗改善激素耐药的急性GVHD患者生存

注射MSCs是治疗激素耐药的急性GVHD的一个可行的治疗方法。迫切需要随机临床试验评估不同治疗方法对激素耐药的急性移植物抗宿主病的效果。

Blood:干细胞移植后补充维生素A可能能抑制移植物抗宿主病的发生

这些数据支持了研究人员的假设,即低水平的维生素A积极促进胃肠道发生移植物抗宿主病的概率。未来补充维生素A可能会改善移植结果。