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Gastroenterol：粪钙卫蛋白监测有助于早期发现克罗恩病术后复发

2015-01-24 lijiasu MedSci原创

克罗恩病粪钙卫蛋白复发
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近日，澳大利亚圣文森特医院和墨尔本大学等处的研究人员进行了一项前瞻性随机对照试验，发现监测粪钙卫蛋白（Fecal Calprotectin，FC）有助于早期发现克罗恩病术后复发，最新研究成果在线发表于1月22日的Gastroenterology杂志上。

克罗恩病（Crohn’s disease，CD）肠切除术后复发率较高，术后内镜粘膜监测和对症治疗可减少复发几率。近日，澳大利亚圣文森特医院和墨尔本大学等处的研究人员进行了一项前瞻性随机对照试验，发现监测粪钙卫蛋白（Fecal Calprotectin，FC）有助于早期发现克罗恩病术后复发，最新研究成果在线发表于1月22日的Gastroenterology杂志上。该试验共招募到135例患者参与内镜监测疾病复发的评估能力和预防术后克罗恩病复发的阶梯式治疗。研究人员检测了术前和肉眼病灶全切除术后6、12和18个月的患者粪钙卫蛋白水平、血清C反应蛋白和克罗恩病活动指数（CDAI）得分等。90例患者在术后6个月、所有患者在术后18个月还进行了回结肠镜检查。研究结果显示，共检测了135例患者319例样本的粪钙卫蛋白水平。平均粪钙卫蛋白浓度由术前的1347 μg/g下降到术后6个月的166 μg/g，但疾病复发（内镜分析，Rutgeerts得分≥i2）患者较病情缓解者水平明显增高（275 μg/g vs 72 μg/g；P<0.001）。术后6个月和18个月粪钙卫蛋白的组合浓度与克罗恩病复发的

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    2015-08-21 jktdtl

    #Gastroenterol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火，同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
    2015-10-11 ms24272190615788285182

    #AST#

    0

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    2015-11-09 zz12341234

    #术后复发#

    0

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    2015-02-13 许安

    #GAS#

    0

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    2015-01-25 ms6832696159214430

    #早期发现#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2063914, encodeId=050d20639148a, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Fri Aug 21 18:18:00 CST 2015, time=2015-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1710779, encodeId=1e051e1077996, content=<a href='/topic/show?id=9a1c289680' target=_blank style='color:#2F92EE;'>#AST#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2896, encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Sun Oct 11 04:18:00 CST 2015, time=2015-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1991804, encodeId=1545199180480, content=<a href='/topic/show?id=ea25610484f' target=_blank style='color:#2F92EE;'>#术后复发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61048, encryptionId=ea25610484f, topicName=术后复发)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62e4433, createdName=zz12341234, createdTime=Mon Nov 09 00:18:00 CST 2015, time=2015-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2071569, encodeId=d36920e1569d0, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Fri Feb 13 09:18:00 CST 2015, time=2015-02-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331297, encodeId=1924133129eee, content=<a href='/topic/show?id=35e7593559a' target=_blank style='color:#2F92EE;'>#早期发现#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59355, encryptionId=35e7593559a, topicName=早期发现)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9cb02500048, createdName=ms6832696159214430, createdTime=Sun Jan 25 15:18:00 CST 2015, time=2015-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=14640, encodeId=634e14640d6, content=这个蛋白现在很火，同道借鉴一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sat Jan 24 14:19:00 CST 2015, time=2015-01-24, status=1, ipAttribution=)]
    2015-01-24 lovetcm

    这个蛋白现在很火，同道借鉴一下

    0

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