BBA-Proteins Proteom:血液生物标记物用于胃癌的早期发现

2014-03-26 佚名 生物谷

近日,Adelaide大学研究人员使用在人癌症患者血液中识别的新的4个生物标记物,为早期检测胃癌提供了新的希望。 胃癌是世界第四大最常见的癌症,是导致癌症死亡的第二大原因。胃癌的早期阶段通常没有症状,因此大多数癌症都没有确诊,直到后期阶段,因此患者存活率很低。 微创内镜手术通常是昂贵的,大多数都是直到癌症晚期才进行的。一种非侵入性,价格低廉的筛选技术,通过一个简单的血液测试早期发现

近日,Adelaide大学研究人员使用在人癌症患者血液中识别的新的4个生物标记物,为早期检测胃癌提供了新的希望。

胃癌是世界第四大最常见的癌症,是导致癌症死亡的第二大原因。胃癌的早期阶段通常没有症状,因此大多数癌症都没有确诊,直到后期阶段,因此患者存活率很低。

微创内镜手术通常是昂贵的,大多数都是直到癌症晚期才进行的。一种非侵入性,价格低廉的筛选技术,通过一个简单的血液测试早期发现胃癌,可以使患者生存预后产生巨大差异。

发表在杂志Biochimica et Biophysica Acta杂志上的这项研究中,研究人员已经确定了四个新的蛋白质,在胃癌患者血液中浓度发生改变。在这项最新研究中,在37位胃癌患者血清样本中(其中包括11早期癌症患者),以及对照包括健康志愿者和非癌性其他胃部疾病患者中,四个蛋白质的水平不同。

所有四种蛋白质afamin、凝聚素(Clusterin)、结合珠蛋白(Haptoglobin)和维生素D结合蛋白(vitamin D binding protein,VDBP),在鉴别胃癌和健康对照者中都优于当前临床标志物CA72-4。

原始出处:

Julia M. Humphries, Megan A.S. Penno, Florian Weiland, Manuela Klingler-Hoffmann, Agnieszka Zuber, Alex Boussioutas, Matthias Ernst, Peter Hoffmann.Identification and validation of novel candidate protein biomarkers for the detection of human gastric cancer.BBA-Proteins Proteom Feb 7 2014


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    2014-08-31 wjywjy
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    2015-02-02 zll0625
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    2014-03-28 sunylz
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