BMJ case report:糖尿病能逆转?间断性“饿”肚子或奏效

2018-10-16 卢芳 中国循环杂志

没有想不到,只有做不到:3个靠吃药打胰岛素控制糖尿病的男士,没有手术,其糖尿病居然逆转了。这是近日刊登在BMJ Case Reports上的活生生的病例。其中,逆转糖尿病的诀窍就是会“饿”肚子,即有计划地去禁食。3位患者年龄在40~67岁,他们平日靠降糖药和胰岛素来控制血糖,此外都有高血压和高胆固醇血症。预计禁食10个月。不过在有计划地科学地“饿”了1个月时,奇迹就出现了:这3个人血糖控制良好,均

没有想不到,只有做不到:3个靠吃药打胰岛素控制糖尿病的男士,没有手术,其糖尿病居然逆转了。

这是近日刊登在BMJ Case Reports上的活生生的病例。其中,逆转糖尿病的诀窍就是会“饿”肚子,即有计划地去禁食。

3位患者年龄在40~67岁,他们平日靠降糖药和胰岛素来控制血糖,此外都有高血压和高胆固醇血症。预计禁食10个月。

不过在有计划地科学地“饿”了1个月时,奇迹就出现了:这3个人血糖控制良好,均无需注射胰岛素了,其中1人甚至只用了5天就“戒”了胰岛素。

禁食10个月时,3人中有2人停服了所有降糖药,第3人则4种药物停服了3种。

空腹血糖和糖化血红蛋白的读数也很喜人,均显着降低。此外,3人毫不意外地都苗条了,减了10%~18%的体重。

效果这么好?怎么“饿”?

据悉,其中两位每隔1天禁食1天,第三位则保持一周有3天“饿”一下自己。

不过在“挨饿”的那天,并非滴水滴食不进,是可以喝点水、低热量的茶或咖啡,以及肉汤,晚上还允许吃一顿低热量的食物。

3个人均表示,这样的禁食没太多困难。

不过值得一提的是,这3位患者在开始禁食前,均参加了时长6小时的营养训练培训,其中包括糖尿病是如何发展和危害健康的,胰岛素抵抗是个啥,如何健康饮食,以及如何通过饮食来控制糖尿病。

报告这些病例的医生谨慎地指出,这是一项观察性研究,且仅仅3例,以此3例断论可在更多患者中治疗成功尚有欠缺。

不过“使用治疗性禁食方案来治疗2型糖尿病还是之前闻所未闻的,这些案例提示,24小时禁食方案有助于显着逆转或减少使用各类降糖药包括胰岛素。”作者指出。

原始出处:Furmli S, Elmasry R, Ramos M,et al. Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin. BMJ Case Reports. 2018 Oct 9

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    2019-03-04 Homburg
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    2019-07-14 gaoxiaoe
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    2018-11-19 charl1234567
  6. [GetPortalCommentsPageByObjectIdResponse(id=2018182, encodeId=29d7201818270, content=<a href='/topic/show?id=1dfe9e25414' target=_blank style='color:#2F92EE;'>#间断性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97254, encryptionId=1dfe9e25414, topicName=间断性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Mon Mar 04 08:42:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632781, encodeId=daef1632e8126, content=<a href='/topic/show?id=10a09e25096' target=_blank style='color:#2F92EE;'>#间断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97250, encryptionId=10a09e25096, topicName=间断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Dec 06 14:42:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782641, encodeId=8ab51e82641ca, content=<a href='/topic/show?id=cff1413333' target=_blank style='color:#2F92EE;'>#case report#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4133, encryptionId=cff1413333, topicName=case report)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jan 07 02:42:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848618, encodeId=aec118486182e, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Jul 14 18:42:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027951, encodeId=0158202e951f3, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Mon Nov 19 13:42:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624898, encodeId=020c162489888, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Oct 18 12:42:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041910, encodeId=2920104191062, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 17 00:42:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349574, encodeId=a1c63495e4da, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 16 22:27:16 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-18 yaanren
  7. [GetPortalCommentsPageByObjectIdResponse(id=2018182, encodeId=29d7201818270, content=<a href='/topic/show?id=1dfe9e25414' target=_blank style='color:#2F92EE;'>#间断性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97254, encryptionId=1dfe9e25414, topicName=间断性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Mon Mar 04 08:42:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632781, encodeId=daef1632e8126, content=<a href='/topic/show?id=10a09e25096' target=_blank style='color:#2F92EE;'>#间断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97250, encryptionId=10a09e25096, topicName=间断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Dec 06 14:42:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782641, encodeId=8ab51e82641ca, content=<a href='/topic/show?id=cff1413333' target=_blank style='color:#2F92EE;'>#case report#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4133, encryptionId=cff1413333, topicName=case report)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jan 07 02:42:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848618, encodeId=aec118486182e, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Jul 14 18:42:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027951, encodeId=0158202e951f3, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Mon Nov 19 13:42:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624898, encodeId=020c162489888, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Oct 18 12:42:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041910, encodeId=2920104191062, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 17 00:42:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349574, encodeId=a1c63495e4da, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 16 22:27:16 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-17 misszhang

    谢谢MedSci提供最新的资讯

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2018182, encodeId=29d7201818270, content=<a href='/topic/show?id=1dfe9e25414' target=_blank style='color:#2F92EE;'>#间断性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97254, encryptionId=1dfe9e25414, topicName=间断性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Mon Mar 04 08:42:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1632781, encodeId=daef1632e8126, content=<a href='/topic/show?id=10a09e25096' target=_blank style='color:#2F92EE;'>#间断#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97250, encryptionId=10a09e25096, topicName=间断)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Thu Dec 06 14:42:00 CST 2018, time=2018-12-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1782641, encodeId=8ab51e82641ca, content=<a href='/topic/show?id=cff1413333' target=_blank style='color:#2F92EE;'>#case report#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4133, encryptionId=cff1413333, topicName=case report)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Jan 07 02:42:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1848618, encodeId=aec118486182e, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sun Jul 14 18:42:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027951, encodeId=0158202e951f3, content=<a href='/topic/show?id=7c9a41324e' target=_blank style='color:#2F92EE;'>#case#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4132, encryptionId=7c9a41324e, topicName=case)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=62a7397, createdName=charl1234567, createdTime=Mon Nov 19 13:42:00 CST 2018, time=2018-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624898, encodeId=020c162489888, content=<a href='/topic/show?id=0333412062' target=_blank style='color:#2F92EE;'>#Cas#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4120, encryptionId=0333412062, topicName=Cas)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=411420689333, createdName=yaanren, createdTime=Thu Oct 18 12:42:00 CST 2018, time=2018-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041910, encodeId=2920104191062, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Oct 17 00:42:00 CST 2018, time=2018-10-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=349574, encodeId=a1c63495e4da, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue Oct 16 22:27:16 CST 2018, time=2018-10-16, status=1, ipAttribution=)]
    2018-10-16 天地飞扬

    了解一下,谢谢分享!

    0

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9月1日,《营养学杂志》发表了一项来自丹麦癌症协会研究中心的文章,这项研究对丹麦55465名志愿者(26251名男性和29214名女性,基线年龄为50-65岁)进行了15年的随访,收集了他们饮食和生活方式等信息,发现全麦饮食与显着降低2型糖尿病的风险有关!在全麦摄入量最高的分组中,男性2型糖尿病风险比全麦摄入量最低的分组降低34%,女性降低22%!

关于糖尿病的预防,竟然还可以这么干

2018年9月,《Lancet Diabetes Endocrinol》在线发表了一项研究,旨在评估:基于T2DM病理生理的治疗方法能否预防糖尿病高危人群的疾病进展(T2DM的发生)。原文链接:https://www.thelancet.com/journals/landia/article/PIIS2213-8587(18)30234-1/fulltext这篇文章是Defronzo教授团队进

当糖尿病遇上便秘,该如何是好?

糖尿病容易合并便秘,尤其多见于血糖控制不佳与老年糖尿病患者。便秘可能会导致糖尿病患者眼底出血、失明及心衰。糖尿病患者便秘的原因很多,应查清原因,在医师指导下改善生活方式,合理用药。

JACC:糖尿病患者强化降压 心血管风险会降低?

2018年9月,发表于《J Am Coll Cardiol》上的一项研究,考察了对糖尿病成人患者普遍强化血压(BP)治疗的效果。

Brit J Cancer:睾丸癌患者主动脉旁放射治疗后患糖尿病的风险如何?

由此可见,与仅接受手术治疗相比,主动脉旁照射与TC幸存者糖尿病风险增加有关。

JAHA:血压<130/80mmHg的糖尿病患者心血管结局更差

对有心血管危险因素的糖尿病患者的理想血压管理尚存在争议。本研究纳入了EXAMINE临床研究中的5380名2型糖尿病伴近期冠心病患者。根据美国心脏病学会的2015年指南和2017年美国糖尿病学会指南,收缩压在131-140mmHg,舒张压在81-90mmHg是被推荐的理想血压。血压与心血管发表风险呈U型相关。与理想血压相比,收缩压<130mmHg或/和收缩压<80mmHg可以明显增加患者主要心血管不