JCLA:循环纤维蛋白原与前白蛋白比值是一种有前途的结直肠癌诊断生物标志物?

2019-05-16 不详 网络

前期研究表明,炎症和营养与结直肠癌的发生和发展密切相关。本研究旨在探讨FAR (FAR = 100*纤维蛋白原/白蛋白)和FPR (FPR =纤维蛋白原/前‐白蛋白)在CRC中的诊断价值。

前期研究表明,炎症和营养与直肠癌的发生和发展密切相关。本研究旨在探讨FAR (FAR = 100*纤维蛋白原/白蛋白)FPR (FPR =纤维蛋白原/前‐白蛋白)CRC中的诊断价值。

研究人员在455名新诊断CRC患者、455名健康个体和455名结直肠息肉的良性对照者中,计算了中性粒细胞‐‐淋巴细胞比值(NLR)FPRFAR。应用ROC曲线(receiver operating characteristic curve, ROC)评价biomarkerCRC的诊断价值。采用Logistic回归分析,评价判断直肠癌与良性疾病的危险因素。此外,联合生物标志物用于鉴别CRC和良性疾病。

研究结果显示,CRC患者中性粒细胞‐淋巴细胞比值、FARFPR明显高于良性或健康对照组(P < 0.05)ROC分析显示FARFPRCRC的诊断效果优于NLR。此外,在logistic回归分析中,FPRNLR、癌胚抗原(CEA)、碳水化合物抗原199 (CA199)与良性疾病和CRC的分化显著相关。FPRCEACA199联合应用ROC曲线下面积最大(AUC = 0.845,敏感性= 67.9%,特异性= 85.3%,阳性预测值= 83.5%,阴性预测值= 70.9%)

研究表明,纤维蛋白原/前‐白蛋白可能是一种有用的CRC诊断生物标志物,结合FPRCEACA199可以显著提高诊断CRC与良性结直肠疾病的疗效。

原始出处:

Fan Sun,  YuAo Tan ,Circulating fibrinogen to prealbumin ratio is a promising biomarker for diagnosis of colorectal cancer

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    2019-05-18 珙桐
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