Ann Rheum Dis:银屑病关节炎病人需预防心血管事件的发生

2015-10-25 candy 译 MedSci原创

目标:评估银屑病关节炎(PsA)患者心血管事件的发生率及危险因素。方法:进行进行队列研究,研究对象从一家大型银屑病关节炎(PsA)医院中招募,在1978年-2013年间进行随访调查。参与者根据标准协议做间隔6-12个月的评估。收集的资料包括人口统计资料、生活习惯、医疗史、药物使用史及与银屑病关节炎(PsA)相关的结果。主要的结果是一个复合的主要心血管终点,包括心肌梗塞、缺血性脑卒中、血管成形术和心

目标:评估银屑病关节炎(PsA)患者心血管事件的发生率及危险因素。

方法:进行队列研究,研究对象从一家大型银屑病关节炎(PsA)医院中招募,在1978年-2013年间进行随访调查。参与者根据标准协议做间隔6-12个月的评估。收集的资料包括人口统计资料、生活习惯、医疗史、药物使用史及与银屑病关节炎(PsA)相关的结果。主要的结果是一个复合的主要心血管终点,包括心肌梗塞、缺血性脑卒中、血管成形术和心血管死亡。疾病活动的特征和心血管事件发生的关联使用Cox比例风险模型进行评估。

结果:对1091例前列腺特异抗原进行了分析。在随访期间,发生了共104例心血管事件。相当大比例的患者发生心血管事件(19.8%的患者,年龄为70岁;30.1%的患者,年龄为80岁)。在过去的几十年里(从1978-2013年),没有观察到心血管事件存在发展的趋势(P=0.73)。在多变量分析中,下列变量是主要心血管事件的独立预测因素:高血压(相对危险度(RR)为1.81,P = 0.015),糖尿病(RR 2.72,P<0.001)和指形的个数(RR 1.20,P<0.001)。沉降率仅仅是女性患者的显著预测因子(RR = 1.83,P = 0.02)。

结论:银屑病关节炎病人在疾病发展过程中,心血管事件显著增加。增加的心血管风险与传统的心血管危险因素和疾病活动有相关性。


原始出处


Eder L, Wu Y, Chandran V, Cook R, Gladman DD.Incidence and predictors for cardiovascular events in patients with psoriatic arthritis.Ann Rheum Dis. 2015 Oct 22. 


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