Nature:人类肠道菌群摄取营养物质的过程被破译

2017-01-15 佚名 生物谷

纽卡斯尔大学的研究人员最近在国际学术期刊Nature上发表了一项最新研究进展,他们通过结构生物学方法深入了解了肠道细菌摄取营养物质的过程,这为众多肠道菌群研究提供了重要的基础。人类肠道中定植着极端丰富的细菌群体,我们称之为肠道菌群。最近一些研究表明肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联。在人类肠道这种存在高度竞争性的环境中,肠道菌群的功能和组成依赖于每一种细菌获


纽卡斯尔大学的研究人员最近在国际学术期刊Nature上发表了一项最新研究进展,他们通过结构生物学方法深入了解了肠道细菌摄取营养物质的过程,这为众多肠道菌群研究提供了重要的基础。

人类肠道中定植着极端丰富的细菌群体,我们称之为肠道菌群。最近一些研究表明肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联。在人类肠道这种存在高度竞争性的环境中,肠道菌群的功能和组成依赖于每一种细菌获取营养物质的能力。

细菌获取营养物质的过程是由细胞膜上的蛋白机器来执行,对于肠道菌群中的许多细菌来说,该过程是由一个蛋白复合体完成,这种蛋白复合体由一个底物结合蛋白(SusD)和一个通道转运蛋白(SusC)组成。

纽卡斯尔大学的研究人员报道称他们首次纯化并通过X射线晶体成像技术确定了SusCD复合体的三维原子结构,明确了营养物质如何转运到细菌内部。

SucCD复合体在发挥功能时就像一个脚踏垃圾桶,SucC就像桶身,而SucD就像上面的盖子。当出现底物时,盖子就会打开,在捕获到底物以后,盖子关闭底物通过桶身进入到细胞内。

这项研究为了解肠道菌群如何发挥功能以及人类与肠道菌群的共生关系提供了重要的结构基础。同时也为借助肠道菌群干预手段寻找疾病治疗方法提供了新的方向。


原始出处:

Amy J. Glenwright, Karunakar R. Pothula, Satya P. Bhamidimarri, Dror S. Chorev, Arnaud Baslé, Susan J. Firbank, Hongjun Zheng, Carol V. Robinson, Mathias Winterhalter, Ulrich Kleinekathöfer, David N. Bolam & Bert van den Berg.Structural basis for nutrient acquisition by dominant members of the human gut microbiota.Nature.DOI: 10.1038/nature20828 

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    2017-05-06 liye789132251
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    2017-01-18 大爰

    再次学习并分享感谢!!

    0

  3. 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08:40:47 CST 2017, time=2017-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170680, encodeId=e62b1e06805d, content=新东西,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161205/IMG5844EA53C3AFE6668.jpg, createdBy=f04a1990753, createdName=天山医者, createdTime=Mon Jan 16 08:45:35 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170679, encodeId=d2751e067911, content=新的知识学习!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jan 16 08:42:45 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170662, encodeId=aa251e0662d9, content=最新科技,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Jan 16 07:43:16 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170659, encodeId=e9881e0659e7, content=好的??, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161008/IMG57F86839881C22340.jpg, createdBy=38251962317, createdName=后宫三千, createdTime=Mon Jan 16 07:35:56 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170649, encodeId=db621e06492a, content=肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Mon Jan 16 07:08:10 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170648, encodeId=4ae71e0648b4, content=学习了……回很不错呢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-01-17 1e0f8808m18(暂无匿称)

    学习了,学习了,学习了!

    0

  5. 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08:42:45 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170662, encodeId=aa251e0662d9, content=最新科技,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Jan 16 07:43:16 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170659, encodeId=e9881e0659e7, content=好的??, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161008/IMG57F86839881C22340.jpg, createdBy=38251962317, createdName=后宫三千, createdTime=Mon Jan 16 07:35:56 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170649, encodeId=db621e06492a, content=肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Mon Jan 16 07:08:10 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170648, encodeId=4ae71e0648b4, content=学习了……回很不错呢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPo3ccLBxicVKw4KKYicbQ5Nax0L6j1ZsavUoQm2y7nMaXyuuIT9Xz0ibRkOXMB7E1vscNvVwRwfCgib/0, createdBy=a0982010198, createdName=Tips, createdTime=Mon Jan 16 07:06:02 CST 2017, time=2017-01-16, status=1, ipAttribution=)]
    2017-01-16 天山医者

    新东西,学习了

    0

  6. 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08:42:45 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170662, encodeId=aa251e0662d9, content=最新科技,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Jan 16 07:43:16 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170659, encodeId=e9881e0659e7, content=好的??, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161008/IMG57F86839881C22340.jpg, createdBy=38251962317, createdName=后宫三千, createdTime=Mon Jan 16 07:35:56 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170649, encodeId=db621e06492a, content=肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Mon Jan 16 07:08:10 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170648, encodeId=4ae71e0648b4, content=学习了……回很不错呢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPo3ccLBxicVKw4KKYicbQ5Nax0L6j1ZsavUoQm2y7nMaXyuuIT9Xz0ibRkOXMB7E1vscNvVwRwfCgib/0, createdBy=a0982010198, createdName=Tips, createdTime=Mon Jan 16 07:06:02 CST 2017, time=2017-01-16, status=1, ipAttribution=)]
    2017-01-16 大爰

    新的知识学习!!

    0

  7. 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    2017-01-16 天涯183

    最新科技,学习了

    0

  8. 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08:42:45 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170662, encodeId=aa251e0662d9, content=最新科技,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Mon Jan 16 07:43:16 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170659, encodeId=e9881e0659e7, content=好的??, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161008/IMG57F86839881C22340.jpg, createdBy=38251962317, createdName=后宫三千, createdTime=Mon Jan 16 07:35:56 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170649, encodeId=db621e06492a, content=肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Mon Jan 16 07:08:10 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170648, encodeId=4ae71e0648b4, content=学习了……回很不错呢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPo3ccLBxicVKw4KKYicbQ5Nax0L6j1ZsavUoQm2y7nMaXyuuIT9Xz0ibRkOXMB7E1vscNvVwRwfCgib/0, createdBy=a0982010198, createdName=Tips, createdTime=Mon Jan 16 07:06:02 CST 2017, time=2017-01-16, status=1, ipAttribution=)]
    2017-01-16 后宫三千

    好的??

    0

  9. 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createdTime=Mon Jan 16 07:35:56 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170649, encodeId=db621e06492a, content=肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160916/IMG57DBEDBBA66BD2947.jpg, createdBy=3b181951777, createdName=ren1mw, createdTime=Mon Jan 16 07:08:10 CST 2017, time=2017-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170648, encodeId=4ae71e0648b4, content=学习了……回很不错呢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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    2017-01-16 ren1mw

    肠道菌群对人类健康非常重要,与自身免疫疾病,癌症和肥胖都有重要关联

    0

  10. 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    2017-01-16 Tips

    学习了……回很不错呢!

    0

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这个新年当你试图改善你的饮食习惯,你的肠道微生物群可能变化不大。发表在 Cell Host & Microbe 一项新研究中,研究人员探索了:小鼠从无限制的美国饮食转换到健康的、卡路里限制的、偏素食的饮食,它们对这样的改变并未及时响应。研究者发现某些人类肠道细菌需要新年丢失,变更的饮食计划才得以成功。 Griffin等人的发现:对饮食干预的微生物群响应的幅度随个体而变化,

Cell Host Microbe:想从健康饮食中获益?那你得问问肠道菌群答不答应

如果你的新年决心是采取健康饮食,这里需要关注的是肠道微生物的作用。近日,来自圣路易斯华盛顿大学(WUSTL)基因组学和系统生物学中心的一项新研究发现表明,肠道菌群的多样化受典型的西方饮食的影响,该研究结果已发表于Cell Host & Microbe。此外,研究还发现,西方饮食所影响的肠道菌群可能会减弱健康、卡路里较少和植物性饮食的效果。西方饮食(有时被称为“美国标准饮食”)通常被定义为含