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Adv Healthc Mater：Laponite扩散凝胶可作为骨组织工程支架有效促进骨再生

2018-06-20 MedSci MedSci原创

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Laponite纳米颗粒在组织工程领域因其蛋白质相互作用，凝胶形成性质及成骨生物活性而受到关注。虽然越来越多的研究人员对Laponite的成骨特性感兴趣，但是Laponite胶体凝胶在宿主应答干细胞群的成骨分化的应用尚未有研究。本研究中，研究人员证明了利用Laponite的凝胶形成特性产生用于成骨的可注射生物活性微环境的潜力。采用扩散/透析凝胶化方法，可从生理流体中的可注射触变Laponite悬浮

Laponite纳米颗粒在组织工程领域因其蛋白质相互作用，凝胶形成性质及成骨生物活性而受到关注。虽然越来越多的研究人员对Laponite的成骨特性感兴趣，但是Laponite胶体凝胶在宿主应答干细胞群的成骨分化的应用尚未有研究。本研究中，研究人员证明了利用Laponite的凝胶形成特性产生用于成骨的可注射生物活性微环境的潜力。

采用扩散/透析凝胶化方法，可从生理流体中的可注射触变Laponite悬浮液快速形成稳定的透明凝胶。在与缓冲盐水或血清接触时，由于纳米颗粒相互作用的重组而分别形成凝胶硬度增加五倍和十倍的纳米多孔凝胶网络。探究Laponite扩散凝胶作为含骨骼干细胞的成骨微环境。Laponite薄膜支持2D中人骨髓基质细胞的细胞粘附、增殖和分化。与3D颗粒培养对照相比，Laponite凝胶包封明显增强成骨蛋白的表达。在二维和三维条件下，细胞相关的矿化作用强烈增强。

综上所述，该研究结果表明，Laponite扩散凝胶提供了作为生物活性和临床相关骨组织工程支架的巨大潜力。

原始出处：

Shi P, Kim YH, et al., Self-Assembling Nanoclay Diffusion Gels for Bioactive Osteogenic Microenvironments. Adv Healthc Mater. 2018 Jun 17:e1800331. doi: 10.1002/adhm.201800331.

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    2019-02-18 shizhenshan

    #ALT#

    0

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    2019-04-19 linagood

    #骨组织工程#

    0

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    2018-07-02 diushouji

    #骨组织#

    0

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    2018-10-03 LSJ122

    #LAP#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1861231, encodeId=498c186123164, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Feb 18 21:01:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070081, encodeId=a40720e0081f3, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Apr 19 10:01:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076337, encodeId=f4dd20e633737, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jul 02 13:01:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734669, encodeId=f5dd1e346699a, content=<a href='/topic/show?id=2239106951c' target=_blank style='color:#2F92EE;'>#LAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10695, encryptionId=2239106951c, topicName=LAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06de33803044, createdName=LSJ122, createdTime=Wed Oct 03 06:01:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417178, encodeId=fb41141e1783f, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460967, encodeId=1cbf146096e8b, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472132, encodeId=c38214e213277, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621730, encodeId=f34f1621e3071, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-22 zhu_jun9838

    #组织工程#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1861231, encodeId=498c186123164, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Feb 18 21:01:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070081, encodeId=a40720e0081f3, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Apr 19 10:01:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076337, encodeId=f4dd20e633737, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jul 02 13:01:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734669, encodeId=f5dd1e346699a, content=<a href='/topic/show?id=2239106951c' target=_blank style='color:#2F92EE;'>#LAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10695, encryptionId=2239106951c, topicName=LAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06de33803044, createdName=LSJ122, createdTime=Wed Oct 03 06:01:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417178, encodeId=fb41141e1783f, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460967, encodeId=1cbf146096e8b, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472132, encodeId=c38214e213277, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621730, encodeId=f34f1621e3071, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-22 lishizhe

    #凝胶#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1861231, encodeId=498c186123164, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Feb 18 21:01:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070081, encodeId=a40720e0081f3, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Apr 19 10:01:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076337, encodeId=f4dd20e633737, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jul 02 13:01:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734669, encodeId=f5dd1e346699a, content=<a href='/topic/show?id=2239106951c' target=_blank style='color:#2F92EE;'>#LAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10695, encryptionId=2239106951c, topicName=LAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06de33803044, createdName=LSJ122, createdTime=Wed Oct 03 06:01:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417178, encodeId=fb41141e1783f, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460967, encodeId=1cbf146096e8b, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472132, encodeId=c38214e213277, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621730, encodeId=f34f1621e3071, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-22 lsj630

    #骨再生#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1861231, encodeId=498c186123164, content=<a href='/topic/show?id=401a23e102' target=_blank style='color:#2F92EE;'>#ALT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2371, encryptionId=401a23e102, topicName=ALT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ccbd84, createdName=shizhenshan, createdTime=Mon Feb 18 21:01:00 CST 2019, time=2019-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2070081, encodeId=a40720e0081f3, content=<a href='/topic/show?id=9ced1018209a' target=_blank style='color:#2F92EE;'>#骨组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101820, encryptionId=9ced1018209a, topicName=骨组织工程)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1376173, createdName=linagood, createdTime=Fri Apr 19 10:01:00 CST 2019, time=2019-04-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2076337, encodeId=f4dd20e633737, content=<a href='/topic/show?id=940410181964' target=_blank style='color:#2F92EE;'>#骨组织#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101819, encryptionId=940410181964, topicName=骨组织)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c192448, createdName=diushouji, createdTime=Mon Jul 02 13:01:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734669, encodeId=f5dd1e346699a, content=<a href='/topic/show?id=2239106951c' target=_blank style='color:#2F92EE;'>#LAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10695, encryptionId=2239106951c, topicName=LAP)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06de33803044, createdName=LSJ122, createdTime=Wed Oct 03 06:01:00 CST 2018, time=2018-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417178, encodeId=fb41141e1783f, content=<a href='/topic/show?id=8b72e769056' target=_blank style='color:#2F92EE;'>#组织工程#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77690, encryptionId=8b72e769056, topicName=组织工程)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c62f3243688, createdName=zhu_jun9838, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460967, encodeId=1cbf146096e8b, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e09e6383467, createdName=lishizhe, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472132, encodeId=c38214e213277, content=<a href='/topic/show?id=d068101610b9' target=_blank style='color:#2F92EE;'>#骨再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101610, encryptionId=d068101610b9, topicName=骨再生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a4cf7208806, createdName=lsj630, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1621730, encodeId=f34f1621e3071, content=<a href='/topic/show?id=5f1386329e' target=_blank style='color:#2F92EE;'>#Health#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8632, encryptionId=5f1386329e, topicName=Health)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8d2020283215, createdName=yyanpro@28cn.c, createdTime=Fri Jun 22 04:01:00 CST 2018, time=2018-06-22, status=1, ipAttribution=)]
    2018-06-22 yyanpro@28cn.c

    #Health#

    0