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J Biomater Appl：牺牲模板法合成新型支架可为细胞的增殖提供良好的生存环境

2018-01-20 MedSci MedSci原创

牺牲模板法生物活性玻璃组织工程
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与块状结构相比，模仿天然细胞外基质的三维纳米纤维支架可增加细胞附着和分化，在组织工程和再生医学具有巨大的应用前景。在这项工作中，研究人员首次采用牺牲模板法制备了三维多孔纳米纤维58S生物玻璃支架。在此过程中，使用天然的三维纳米纤维细菌纤维素作为牺牲模板，通过溶胶-凝胶法在其上沉积前体58S玻璃。 SEM和TEM结果证实所制备的58S支架能够继承细菌纤维素的三维纳米纤维特征。通过氮气吸附-解吸对介孔

与块状结构相比，模仿天然细胞外基质的三维纳米纤维支架可增加细胞附着和分化，在组织工程和再生医学具有巨大的应用前景。

在这项工作中，研究人员首次采用牺牲模板法制备了三维多孔纳米纤维58S生物玻璃支架。在此过程中，使用天然的三维纳米纤维细菌纤维素作为牺牲模板，通过溶胶-凝胶法在其上沉积前体58S玻璃。 SEM和TEM结果证实所制备的58S支架能够继承细菌纤维素的三维纳米纤维特征。通过氮气吸附-解吸对介孔结构进行表征，压汞孔隙率测量表明58S支架是高度多孔的，孔隙率为75.1％，并且包含中孔（39.4nm）和大孔（60μm）以及大的BET表面积（127.4 m2 g-1）。体外细胞研究表明，58S支架具有生物活性，且与原代小鼠成骨细胞具有生物相容性，表明58S的纳米纤维结构能够为细胞功能提供合适的环境。

综上所述，该研究结果表明，三维纳米纤维58S支架在骨组织工程和再生医学中具有很大的应用潜力。

原始出处：

Luo H, Zhang Y1, et al., Sacrificial template method for the synthesis of three-dimensional nanofibrous 58S bioglass scaffold and its in vitro bioactivity and cell responses. J Biomater Appl. 2017 Aug;32(2):265-275. doi: 10.1177/0885328217715784. Epub 2017 Jun 15.

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1647171, encodeId=dd2c164e17120, content=<a href='/topic/show?id=5a816806211' target=_blank style='color:#2F92EE;'>#牺牲模板法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68062, encryptionId=5a816806211, topicName=牺牲模板法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc1f23396793, createdName=daviiliu, createdTime=Sat Jul 14 14:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917883, encodeId=3381191e883d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 13 08:35:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281732, encodeId=65a4281e329d, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jan 24 23:56:04 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281417, encodeId=7ff128141ec3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jan 24 01:29:08 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280391, encodeId=e53328039171, content=好办法.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jan 20 15:22:11 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280376, encodeId=83032803e6d9, content=了解了解学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jan 20 15:05:27 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-07-14 daviiliu

    #牺牲模板法#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1647171, encodeId=dd2c164e17120, content=<a href='/topic/show?id=5a816806211' target=_blank style='color:#2F92EE;'>#牺牲模板法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68062, encryptionId=5a816806211, topicName=牺牲模板法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc1f23396793, createdName=daviiliu, createdTime=Sat Jul 14 14:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917883, encodeId=3381191e883d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 13 08:35:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281732, encodeId=65a4281e329d, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jan 24 23:56:04 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281417, encodeId=7ff128141ec3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jan 24 01:29:08 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280391, encodeId=e53328039171, content=好办法.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jan 20 15:22:11 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280376, encodeId=83032803e6d9, content=了解了解学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jan 20 15:05:27 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-04-13 sunylz

    #Bio#

    0

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    2018-01-24 天涯183

    非常好的文章.学习了

    0

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    2018-01-24 三生有幸9135

    学习一下谢谢分享

    0

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    2018-01-20 1e0f8808m18(暂无匿称)

    好办法.学习了.

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1647171, encodeId=dd2c164e17120, content=<a href='/topic/show?id=5a816806211' target=_blank style='color:#2F92EE;'>#牺牲模板法#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68062, encryptionId=5a816806211, topicName=牺牲模板法)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=dc1f23396793, createdName=daviiliu, createdTime=Sat Jul 14 14:35:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917883, encodeId=3381191e883d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Fri Apr 13 08:35:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281732, encodeId=65a4281e329d, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Wed Jan 24 23:56:04 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=281417, encodeId=7ff128141ec3, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Wed Jan 24 01:29:08 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280391, encodeId=e53328039171, content=好办法.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sat Jan 20 15:22:11 CST 2018, time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280376, encodeId=83032803e6d9, content=了解了解学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jan 20 15:05:27 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 1dd8c52fm63(暂无匿称)

    了解了解学习学习

    0