Mol Clin Oncol:重度牙周炎可影响胰胆管癌患者的预后

2017-06-18 MedSci MedSci原创

既往一些研究表明牙周炎是癌症发生的一个危险因素。然而,目前尚不清楚牙周炎与胰胆管癌的预后是否相关。本研究旨在探讨牙周炎与胰胆管癌预后之间的关系。 研究共纳入了22名确诊为胰胆管癌的患者进行了分析。评估患者的口腔健康状况,包括牙周炎的严重程度,一般健康状况和生化血清标志物。使用Kaplan Meier法和Cox比例风险模型评估影响胰胆管癌预后的相关因素。 结果,Kaplan Meier分

既往一些研究表明牙周炎是癌症发生的一个危险因素。然而,目前尚不清楚牙周炎与胰胆管癌的预后是否相关。本研究旨在探讨牙周炎与胰胆管癌预后之间的关系。

研究共纳入了22名确诊为胰胆管癌的患者进行了分析。评估患者的口腔健康状况,包括牙周炎的严重程度,一般健康状况和生化血清标志物。使用Kaplan Meier法和Cox比例风险模型评估影响胰胆管癌预后的相关因素。

结果,Kaplan Meier分析表明,低体重指数、高浓度C-反应蛋白(CRP)和严重牙周炎是影响胰胆管癌生存率的重要预后因素。Cox比例风险模型显示,血清糖类抗原19-9浓度[危险比(HR)为1.002;95%置信区间(CI):1-1.004 ]和血清CRP浓度(HR = 2.57;95%可信区间:1.15-5.74)与胰胆管癌的预后显著相关。此外,研究还发现,胰胆管癌患者中,严重牙周炎患者的血清CRP浓度高于非严重牙周炎患者。

因此,该研究发现表明,重度牙周炎可通过促进全身炎症反应间接影响胰胆管癌患者的预后。

原始出处:


Takayuki Maruyama, Takaaki Tomofuji, et al., Association between periodontitis and prognosis of pancreatobiliary tract cancer: A pilot study. Mol Clin Oncol. 2017 May; 6(5): 683–687. Published online 2017 Apr 10. doi:  10.3892/mco.2017.1220.

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time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, 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    2018-05-13 minlingfeng
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    2017-06-20 luominglian113

    学习了,谢谢分享

    0

  4. 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time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-20 游手好闲

    学习了

    0

  5. 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time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
  6. 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ipAttribution=)]
  7. 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time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 xiaotaiyang1

    看看了解一下了,开阔视野

    0

  8. 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Jun 20 04:11:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212377, encodeId=59fb2123e72a, content=看看了解一下了,开阔视野, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:27 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212374, encodeId=cbd22123e43e, content=有可能是反了,但也有可能是互位促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:23:49 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 honghongwuwu

    有可能是反了,但也有可能是互位促进

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1864950, encodeId=67b018649507e, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Sun May 13 06:11:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1934336, encodeId=f9dc1934336ad, content=<a href='/topic/show?id=5d1195823b1' target=_blank style='color:#2F92EE;'>#重度牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95823, encryptionId=5d1195823b1, topicName=重度牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a35a460, 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encodeId=eec714505326e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 04:11:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628287, encodeId=324e162828ef2, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Tue Jun 20 04:11:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212377, encodeId=59fb2123e72a, content=看看了解一下了,开阔视野, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:27 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212374, encodeId=cbd22123e43e, content=有可能是反了,但也有可能是互位促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:23:49 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 lovetcm

    这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重

    0

  10. 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encodeId=eec714505326e, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Tue Jun 20 04:11:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1628287, encodeId=324e162828ef2, content=<a href='/topic/show?id=9a4e83503e4' target=_blank style='color:#2F92EE;'>#胆管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83503, encryptionId=9a4e83503e4, topicName=胆管)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c21721182790, createdName=cmj15wellington, createdTime=Tue Jun 20 04:11:00 CST 2017, time=2017-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212377, encodeId=59fb2123e72a, content=看看了解一下了,开阔视野, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sun Jun 18 16:27:27 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212374, encodeId=cbd22123e43e, content=有可能是反了,但也有可能是互位促进, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJT6l93IMYI4yHbuQ6SeZ7HEkJw5o50qBMUibIGVDNqNvTr8ic1wUfHWIIiardvrMQOQRl3pbocQ7G4Q/0, createdBy=434d1527336, createdName=honghongwuwu, createdTime=Sun Jun 18 16:23:49 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212354, encodeId=744e2123540a, content=这样研究应该反了,可能是因为免疫功能下降是根本原因,一方面引发肿瘤的增长较快,另一方面引发口腔的炎症加重, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 18 14:35:45 CST 2017, time=2017-06-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212341, encodeId=7b272123415c, content=牙齿保健不可忽视, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun Jun 18 14:03:46 CST 2017, time=2017-06-18, status=1, ipAttribution=)]
    2017-06-18 楠博One

    牙齿保健不可忽视

    0

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