Heart:急性心力衰竭患者低钠血症及其预后价值与右心室功能障碍有关!

2017-10-28 xing.T MedSci原创

由此可见,AHF患者中低钠血症在右心室功能障碍患者中更常见。右心室功能障碍,而非低钠血症,明显与患者预后相关。因此,在HF风险模型中应考虑采用右心室功能障碍代替低钠血症。

低钠血症是一个已知的心脏衰竭患者临床结局的预测因子。然而,机制尚不清楚。以前的报告表明低钠血症与右心衰相关。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员试图评估右心室功能障碍和低钠血症之间的相关性,以及这种关系对急性心力衰竭(AHF)患者预后的影响。

研究人员对韩国急性心力衰竭登记中心的患者进行巢式病例对照研究。在2011年至2014年期间,2935例AHF患者被前瞻性招募入研究, 116例患者为重度持续性低钠血症,定义为入院血清钠水平低于130mmol/L以及出院<135mmol/L,基于低钠血症倾向得分匹配了232例对照者。研究人员采用超声心动图的面积分数变化(FAC)评估了右心室功能。

右心室功能障碍(FAC<35%)多见于重度持续性低钠血症的患者,相比于那些对照者(81% vs. 33.6%,P<0.001)。低钠血症与右心室功能障碍密切相关(比值比为8,95%可信区间为 4.50-14.22,P<0.001),但与左心室功能不全无关(调整后的比值比为1.21,95%可信区间为0.74-1.50,P=0.308)。右心室功能障碍是全因死亡的独立预测因素,对低钠血症进行调整后(调整后的风险比为2.20,95%可信区间为1.53-3.15,P<0.001),而低钠血症不是全因死亡的独立预测因素(调整后的风险比为1.33,95%可信区间为0.94-1.87,P=0.108)。

由此可见,AHF患者中低钠血症在右心室功能障碍患者中更常见。右心室功能障碍,而非低钠血症,明显与患者预后相关。因此,在HF风险模型中应考虑采用右心室功能障碍代替低钠血症。

原始出处:

Heesun Lee,et al. Hyponatraemia and its prognosis in acute heart failure is related to right ventricular dysfunction. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-312084

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    2017-10-30 zhaojie88
  4. 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time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577047, encodeId=b47f15e70479d, content=<a href='/topic/show?id=e9413863070' target=_blank style='color:#2F92EE;'>#右心室功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38630, encryptionId=e9413863070, topicName=右心室功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=abfe16361765, createdName=1194695146_61857352, createdTime=Mon Oct 30 00:29:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
  5. 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time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577047, encodeId=b47f15e70479d, content=<a href='/topic/show?id=e9413863070' target=_blank style='color:#2F92EE;'>#右心室功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38630, encryptionId=e9413863070, topicName=右心室功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=abfe16361765, createdName=1194695146_61857352, createdTime=Mon Oct 30 00:29:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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  9. 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time=2017-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577047, encodeId=b47f15e70479d, content=<a href='/topic/show?id=e9413863070' target=_blank style='color:#2F92EE;'>#右心室功能障碍#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38630, encryptionId=e9413863070, topicName=右心室功能障碍)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=abfe16361765, createdName=1194695146_61857352, createdTime=Mon Oct 30 00:29:00 CST 2017, time=2017-10-30, status=1, ipAttribution=)]
    2017-10-30 slcumt
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