CLIN CANCER RES:局灶照射联合系统TGFβ阻断治疗转移性乳腺癌

2018-06-10 MedSci MedSci原创

CLIN CANCER RES近期发表了一篇文章,研究转移性乳腺癌患者放疗期间TGFβ阻断的可行性,有效性以及免疫学影响。

CLIN CANCER RES近期发表了一篇文章,研究转移性乳腺癌患者放疗期间TGFβ阻断的可行性,有效性以及免疫学影响。

研究纳入的转移性乳腺癌患者有至少三处远处转移,接受过至少一种治疗后肿瘤进展,患者随机分为两组,接受1mg/kg fresolimumab或10mg/kg fresolimumab治疗,3周一个周期,共5个周期,同时联合第1周转移部位局灶照射,第7周在另一个转移灶部位重复。收集基线,2周,5周和15周的血液样本分离PBMCs,血浆和血清。研究最终纳入23例患者,中位年龄57岁。1mg/kg组11例患者中5例出现7种3/4级不良反应,10mg/kg组12例患者中2例出现上述不良反应。中位随访12个月,23例患者中20例死亡。10mg/kg组的患者中位总生存情况显着优于1mg/kg组患者。更高的剂量与外周血单核细胞数量增加有关。

文章最后认为,化疗期间TGFβ阻断是可行的且耐受性良好。接受更大剂量fresolimumab治疗的患者系统性免疫反应良好且中位总生存时间更长。

原始出处:
Silvia C.Formenti,Percy Lee,et al.Focal Irradiation and Systemic TGFβBlockade in Metastatic Breast Cancer.CLIN CANCER RES.June 2018 doi:10.1158/1078-0432.CCR-17-3322

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    2018-08-29 yuanming7
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    2018-09-05 changhe713
  4. 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 11 23:50:35 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323151, encodeId=d1f032315117, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Jun 11 00:17:48 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-15 jihuaijun1112

    学习学习学习

    0

  5. 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 11 23:50:35 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323151, encodeId=d1f032315117, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Jun 11 00:17:48 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-13 jihuaijun1112

    学习学习学习

    0

  6. 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 11 23:50:35 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323151, encodeId=d1f032315117, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Jun 11 00:17:48 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-13 jihuaijun1112

    学习学习学习学习

    0

  7. 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GetPortalCommentsPageByObjectIdResponse(id=1386398, encodeId=6dc9138639874, content=<a href='/topic/show?id=f08293399f9' target=_blank style='color:#2F92EE;'>#转移性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93399, encryptionId=f08293399f9, topicName=转移性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Tue Jun 12 00:06:00 CST 2018, time=2018-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323404, encodeId=d373323404f2, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 11 23:50:35 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323151, encodeId=d1f032315117, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Jun 11 00:17:48 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-12 jihuaijun1112

    学习学习学习

    0

  8. 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  9. 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createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jun 11 23:50:35 CST 2018, time=2018-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323151, encodeId=d1f032315117, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Jun 11 00:17:48 CST 2018, time=2018-06-11, status=1, ipAttribution=)]
    2018-06-11 清风拂面

    谢谢分享学习

    0

  10. 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