Neurology:在TIA患者中Flair血管高信号征的临床意义

2018-03-15 杨中华 脑血管病及重症文献导读

在近端大动脉闭塞或严重狭窄患者中,核磁Flair血管高密度征(Fluid-attenuated inversion recovery vascular hyperintensity, FVH)很常见。它代表了缓慢顺行或逆行的软脑膜侧枝血流,是血流瘀滞的一种无流空现象。随着溶栓治疗的开展,要求应该早期发现灌注缺损和对侧枝血流的进行评价。FVH是检测灌注缺损和侧枝的一种无创方法,在一些缺血性卒中的研究

在近端大动脉闭塞或严重狭窄患者中,核磁Flair血管高密度征(Fluid-attenuated inversion recovery vascular hyperintensity, FVH)很常见。它代表了缓慢顺行或逆行的软脑膜侧枝血流,是血流瘀滞的一种无流空现象。随着溶栓治疗的开展,要求应该早期发现灌注缺损和对侧枝血流的进行评价。FVH是检测灌注缺损和侧枝的一种无创方法,在一些缺血性卒中的研究中进行过评价。然而,在TIA患者中,尽管FVH很常见,但是它的临床意义尚不清楚。

为了探讨DWI阴性的TIA患者FVH和早期缺血性损害的复发[随访DWI影像阳性,FU-DWI(+)]关系,2018年2月来自韩国的Ki-Woong Nam等在Neurology上公布了他们的研究结果。

研究者连续纳入了发病24h内的DWI阴性的TIA患者,并在急性期复查了MRI。FVH定义为Flari局灶或曲线样高信号。调整混淆因素后,评价FVH和FU-DWI(+)之间的关系。并且比较了FU-DWI (+) 和 FU-DWI (-)组患者1年复发性缺血性卒中或TIA的比例。

该研究共纳入了392例DWI阴性的TIA患者,随访MRI发现82例为FU-DWI(+)。在多因素分析中发现FVH是FU-DWI(+)的独立预测因素(adjusted odds ratio [aOR] = 4.77, 95% CI 2.45–9.29, p < 0.001)。MRI检查时间(aOR = 0.49, 95% CI = 0.33–0.70, p < 0.001)和颅内动脉粥样硬化(aOR = 2.07, 95% CI = 1.10–3.92, p = 0.025)与FU-DWI(+)有关,独立于FVH。与FU-DWI(-)组相比,FU-DWI(+)组1年复发缺血性卒中更常见(10.7%vs 3.1%, respectively,p = 0.007)。

最终作者认为对于DWI阴性的TIA患者,FVH与FU-DWI(+)有关。鉴于FU-DWI(+)常见于急性期,出院后预后不良,因此FVH患者应该进行额外的影像学或临床实验室检查。

原始出处:

Nam KW,et al.FLAIR vascular hyperintensities predict early ischemic recurrence in TIA.Neurology. 2018 Feb 27;90(9):e738-e744.

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    2018-09-01 yinhl1978
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    2018-12-07 马龙
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    2018-03-15 医者仁心5538

    学习了

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