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LANCET：一分钟了解镰状细胞病

2017-02-07 MedSci MedSci原创

镰状细胞贫血干细胞
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镰状细胞病是影响全世界数百万人的常见危及生命的血液系统疾病。异常镰状红细胞影响小血管中的血流，这种血管闭塞导致远端组织缺血和炎症，其症状定义为急性疼痛的镰状细胞危象。重复的镰状和进行性溶血性贫血，甚至在亚临床时，导致实质性器官损伤和慢性器官损伤，引起显着的发病率和早期死亡率。目前可用的治疗仅限于输血和羟基脲，干细胞移植可能是一种潜在的治疗疗法。几种新的治疗选择正在开发中，包括基因治疗和基因编辑。最

镰状细胞病是影响全世界数百万人的常见危及生命的血液系统疾病。异常镰状红细胞影响小血管中的血流，这种血管闭塞导致远端组织缺血和炎症，其症状定义为急性疼痛的镰状细胞危象。


重复的镰状和进行性溶血性贫血，甚至在亚临床时，导致实质性器官损伤和慢性器官损伤，引起显着的发病率和早期死亡率。

目前可用的治疗仅限于输血和羟基脲，干细胞移植可能是一种潜在的治疗疗法。几种新的治疗选择正在开发中，包括基因治疗和基因编辑。

最近的进展包括系统性通用筛查卒中风险，改进使用口腔螯合剂和非侵入性MRI测量的铁过载的管理，以及护理诊断装置。

目前的争议包括溶血在镰状细胞病病理生理学中的作用，妊娠的最佳管理以及预防脑血管疾病的策略。

原始出处：
Ware RE, de Montalembert M, Tshilolo L, Abboud MR. Sickle cell disease. Lancet. 2017 Jan 31. pii: S0140-6736(17)30193-9. 

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    2017-08-22 howi

    #Lancet#

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    2017-02-09 1508842480_96220443

    #镰状细胞#

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    2017-02-09 天涯183

    最新研究进展

    0

  4. 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    2017-02-08 1e1a50a1m36(暂无匿称)

    镰状细胞病是影响全世界数百万人的常见危及生命的血液系统疾病。

    0

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    2017-02-08 1e1a50a1m36(暂无匿称)

    异常镰状红细胞影响小血管中的血流，主要有基因治疗和基因编辑

    0

  6. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Wed Feb 08 05:53:03 CST 2017, time=2017-02-08, status=1, ipAttribution=)]
    2017-02-08 Arbbin

    更新有点慢哦(⊙o⊙)哦

    0

  7. 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    2017-02-08 九九消寒

    总结精彩，学习起来

    0

  8. 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOWcPEsEP4FrvDcicue5V6rMkmXmY73KjYP59vQrEdjU89iaN4ZkOhsItlHkmGTjhV3b5S3zOQA4E0/0, createdBy=cc261682151, createdName=卡圣, createdTime=Wed Feb 08 05:53:03 CST 2017, time=2017-02-08, status=1, ipAttribution=)]
    2017-02-08 现在

    学习中！！！！！

    0

  9. 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    2017-02-08 1e0f8808m18(暂无匿称)

    镰状细胞病学习了。

    0

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    2017-02-08 卡圣

    深入浅出

    0

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