JASN:ACE抑制剂和ARB在肾功能受损者中的使用趋势

2019-06-09 xing.T 网络

由此可见,美国成年CKD患者在21世纪初使用ACE抑制剂/ARB的比例有所增加,但由于原因不明,在随后的十年中使用率似乎达到稳定水平,需要研究评估护理和其他因素。

尽管高血压在CKD患者中很常见,并且基于证据的高血压治疗已经发生了很大变化,但是缺乏关于在CKD患者中使用血管紧张素转换酶(ACE)抑制剂或血管紧张素II受体阻滞剂(ARB)的当代和全国代表性信息。

近日,肾脏病领域权威杂志Journal of the American Society of Nephrology上发表一篇研究文章。研究人员评估了1999年至2014年间38885名成年国家健康和营养检查调查参与者ACE抑制剂/ARB使用趋势,这些参与者基于肌酐的eGFR<60 ml/min/1.73 m2或尿白蛋白-肌酐比≥30mg/g。

在7085名CKD患者中,34.9%使用ACE抑制剂/ARB。在所研究的四个时期,使用率显著上升(1999-2002年的比率为25.5%,2003-2006年为33.3%,2007-2010年为39.0%,2011-2014年为40.1%),但在2003年后较为平稳。CKD患者在非西班牙裔白种人和黑人中的使用率显著提高(分别为36.1%和38.2%),西班牙裔人(26.7%)和其他人种(29.3%)的使用率较低。在年龄、性别和人种调整模型中,ACE抑制剂/ARB使用与年份显著相关(与1999-2002年,相比2003-2006年为调整后的比值比[aOR]为1.41; 95%置信区间[95%CI]为1.14至1.74,2007-2010年为1.84; 95%CI为1.48至2.28,2011-2014年为2.02; 95%CI为1.61至2.53);它也与非西班牙裔黑人与非西班牙裔白种人显著相关(aOR为1.40; 95%CI为1.19-1.66)。其他多变量协会包括年龄较大,男性,BMI升高,糖尿病,高血压治疗,心力衰竭,心肌梗塞,健康保险以及上一年内接受医疗护理。

由此可见,美国成年CKD患者在21世纪初使用ACE抑制剂/ARB的比例有所增加,但由于原因不明,在随后的十年中使用率似乎达到稳定水平,需要研究评估护理和其他因素。

原始出处

Daniel P. Murphy,et al.Trends in Angiotensin-Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use among Those with Impaired Kidney Function in the United States.JASN,2019. https://jasn.asnjournals.org/content/early/2019/06/04/ASN.2018100971

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    2020-01-23 shanyongle
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    2020-02-10 jklm09
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    2019-09-23 yese
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    2019-12-24 chenhongpeng
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