BMJ:微生物群在人类健康与疾病中的作用:给临床医师的介绍

2017-04-07 MedSci MedSci原创

关于微生物群系--包括土着菌群和它们的宿主环境--的研究,已经改变了临床医生对微生物和人类健康和疾病的想法。最激进的改变,也许是认识到栖居在我们身体里的大部分微生物都会为整个宿主 - 微生物系统提供重要的生态系统服务。这些服务包括重要资源的生产、营养的生物转化和预防病原微生物的侵害。有益功能的丧失,或由于入侵微生物而引入了适应不良的功能,都可能导致疾病。这篇综述将展示,对土着微生物群落的动力学和功

关于微生物群系--包括土着菌群和它们的宿主环境--的研究,已经改变了临床医生对微生物和人类健康和疾病的想法。最激进的改变,也许是认识到栖居在我们身体里的大部分微生物都会为整个宿主 - 微生物系统提供重要的生态系统服务。这些服务包括重要资源的生产、营养的生物转化和预防病原微生物的侵害。有益功能的丧失,或由于入侵微生物而引入了适应不良的功能,都可能导致疾病。这篇综述将展示,对土着微生物群落的动力学和功能的理解将如何影响我们对微生物在维持体内平衡和引起疾病的方面的观点。本文将讨论破坏微生物群落有益功能将会如何导致疾病;并介绍研究微生物群落的方法,作为使用这些方法的概念框架的一部分;同时还将讨论微生物的具体变化和疾病之间的关联,并能帮助我们理解,对微生物群落的有意操控--无论是恢复缺失功能还是除去有害功能--将会如何引出预防或治疗一系列疾病的新方法。随着关于微生物与健康和疾病的研究的爆炸性增长,本综述旨在为临床医师跟进此生物医学研究领域提供基础。


原始出处:

Young VB. The role of the microbiome in human health and disease: an introduction for clinicians. BMJ. 2017 Mar 15;356:j831. doi: 10.1136/bmj.j831.

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    2017-10-10 gaoxiaoe
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    2017-04-08 1ddf3e1dm99(暂无匿称)

    学习了,谢谢!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1848281, encodeId=43d618482815d, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Tue Oct 10 09:28:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1694528, encodeId=a9c31694528b1, content=<a href='/topic/show?id=2dde25041f2' target=_blank style='color:#2F92EE;'>#人类健康#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25041, encryptionId=2dde25041f2, topicName=人类健康)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=407529676352, createdName=nakerunner, createdTime=Tue Apr 18 12:28:00 CST 2017, time=2017-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1824747, encodeId=25771824e4725, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Sat Sep 09 21:28:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367731, encodeId=6c37136e7315c, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3609256, createdName=zhu_jun9837, createdTime=Sun Apr 09 04:28:00 CST 2017, time=2017-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=186009, encodeId=83751860095e, content=学习了,谢谢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJicFGXtYqfjGiaibNdjOiaRgkexnXiciaDeXaLiaKicovcicDugdYwRPSnQj3FlfXBwVLB5ANB9PGFyB0kraQ/0, createdBy=35b01663265, createdName=1ddf3e1dm99(暂无匿称), createdTime=Sat Apr 08 16:40:17 CST 2017, time=2017-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=185800, encodeId=cf2d18580002, content=希望能够更好更合理的调控微生物群落来达到疾病的预防和治疗, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=39ef2044909, createdName=zmj4567, createdTime=Fri Apr 07 16:17:13 CST 2017, time=2017-04-07, status=1, ipAttribution=)]
    2017-04-07 zmj4567

    希望能够更好更合理的调控微生物群落来达到疾病的预防和治疗

    0

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