Sci Rep:睡眠窒息症男性中nesfatin-1能够影响下丘脑-垂体-性腺轴么?

2019-08-18 AlexYang MedSci原创

越来越多的证据表明了睡眠窒息症(OSA)能够影响男性下丘脑-垂体-性腺轴(HPG axis)。最近,有研究人员在OSA患者中评估了nesfatin-1与HPG之间的相关性。研究包括了72名新诊断的OSA患者(呼吸暂停低通气指数(AHI)每个档次分别为5≤AHI<15有18名;15≤AHI<30有24名;AHI≥30有30名)和19名AHI<5的对照组。所有的患者均经历了多导睡眠描

越来越多的证据表明了睡眠窒息症(OSA)能够影响男性下丘脑-垂体-性腺轴(HPG axis)。最近,有研究人员在OSA患者中评估了nesfatin-1与HPG之间的相关性。

研究包括了72名新诊断的OSA患者(呼吸暂停低通气指数(AHI)每个档次分别为5≤AHI<15有18名;15≤AHI<30有24名;AHI≥30有30名)和19名AHI<5的对照组。所有的患者均经历了多导睡眠描记和空腹采血测量nesfatin-1、睾丸酮、黄体生成素(LH)、高敏C反应蛋白(hsCRP)、天冬氨酸转氨酶(AST)、丙氨酸氨基转移酶(ALT)、肌酐和葡萄糖。研究发现,2个组之间的LH、nesfatin-1和睾酮水平相似(p=0.87; p=0.24; p=0.08)。nesfatin-1与LH(p=0.71)、睾酮(p=0.38)、AHI (p=0.34)或氧饱和度(ODI) (p=0.69)均没有相关性。

最后,研究人员指出,他们的研究表明了HPG与nesfatin-1在OSA成年男性中没有相关性。可能是nesfatin-1并非OSA成年患者中HPG的干扰因子。

原始出处:

Halina Batura-Gabryel, Barbara Bromińska, Nadia Sawicka-Gutaj et al. Does nesfatin-1 influence the hypothalamic-pituitary-gonadal axis in adult males with obstructive sleep apnoea?.Sci Rep. 05 Aug 2019

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    2019-08-20 xlwang2696
  6. [GetPortalCommentsPageByObjectIdResponse(id=2029958, encodeId=c4e9202995870, content=<a href='/topic/show?id=d493e259c9' target=_blank style='color:#2F92EE;'>#fat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7259, encryptionId=d493e259c9, topicName=fat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=198d2500149, createdName=12498bd5m16暂无昵称, createdTime=Mon Jan 13 07:09:00 CST 2020, time=2020-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435942, encodeId=436c14359422a, content=<a href='/topic/show?id=c8ba20119d1' target=_blank style='color:#2F92EE;'>#下丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20119, encryptionId=c8ba20119d1, topicName=下丘脑)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Tue Aug 20 03:09:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1458268, encodeId=0c3b145826891, content=<a href='/topic/show?id=beff41500cf' target=_blank style='color:#2F92EE;'>#垂体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41500, encryptionId=beff41500cf, topicName=垂体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Tue Aug 20 03:09:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545209, encodeId=31b2154520906, content=<a href='/topic/show?id=3ecbe5565e2' target=_blank style='color:#2F92EE;'>#窒息#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75565, encryptionId=3ecbe5565e2, topicName=窒息)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21f213689241, createdName=1508842480_96220441, createdTime=Tue Aug 20 03:09:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1558309, encodeId=e125155830902, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Tue Aug 20 03:09:00 CST 2019, time=2019-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1564318, encodeId=1696156431817, content=<a href='/topic/show?id=c8a7208e8a8' target=_blank style='color:#2F92EE;'>#丘脑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20878, encryptionId=c8a7208e8a8, topicName=丘脑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=fb8814960000, createdName=xlwang2696, createdTime=Tue Aug 20 03:09:00 CST 2019, time=2019-08-20, status=1, ipAttribution=)]
    2019-08-20 xlwang2696