J Hematol Oncol：转移性乳腺癌的新兴治疗

2017-05-14 肿瘤资讯肿瘤资讯

近期，《Journal of Hematology & Oncology》杂志发表了复旦大学附属肿瘤医院胡夕春教授等的综述，总结了转移性乳腺癌（MBC）的新兴治疗药物。HER2和CDK4/6是乳腺癌目前最重要的治疗靶点，免疫检查点抑制剂前景乐观，尤其是用于三阴性乳腺癌（TNBC）。

近期，《Journal of Hematology & Oncology》杂志发表了复旦大学附属肿瘤医院胡夕春教授等的综述，总结了转移性乳腺癌（MBC）的新兴治疗药物。HER2和CDK4/6是乳腺癌目前最重要的治疗靶点，免疫检查点抑制剂前景乐观，尤其是用于三阴性乳腺癌（TNBC）。

尽管MBC不可治愈，但过去十余年，MBC的治疗取得了重大进展，新兴的靶向治疗，使得MBC患者2-3年的中位总生存（mOS）显着延长。HER2+ MBC一线多西他赛联合曲妥珠单抗和帕妥珠单抗治疗，mOS可达56.5个月；luminal型MBC氟维司群一线治疗的mOS为54.1个月。本综述中，胡教授重点总结了MBC的新兴治疗药物。

· CDK4/6抑制剂

目前进入临床研究的CDK4/6抑制剂包括palbociclib、ribociclib和abemaciclib。基于PALOMA-1研究，FDA批准palbociclib联合来曲唑用于ER+/HER2-绝经后MBC的一线治疗，III期研究PALOMA-2进一步证实了II期研究结果。基于PALOMA-3研究，palbociclib联合氟维司群获批用于既往内分泌治疗进展的 HR+/HER2- MBC。根据MONALEESA-2的研究结果，FDA批准了Ribociclib联合来曲唑作为HR+／HER2-MBC的一线治疗。Abemaciclib联合氟维司群用于HR+/HER2-MBC的III期研究MONARCH 3的结果也即将报道。

· PD-1/PD-L1抑制剂

免疫检查点抑制剂用于TNBC的前景乐观，目前在研的药物包括：Pembrolizumab、Atezolizumab、Nivolumab和Avelumab。

· PARP抑制剂

olaparib和talazoparib正在进行相关研究，入组患者为BRCA1/2突变人群。

· 氟维司群

FALCON研究确立了氟维司群一线治疗绝经后HR+MBC优于阿那曲唑。

· T-DM1

抗体偶联药物（ADC）T-DM1已获批用于HER2+MBC的二线及以上治疗，有望进军一线治疗。

· 创新型化疗药物

包括白蛋白紫杉醇，艾日布林和Utidelone等。

原始出处：

Xichun Hu, et al. Emerging therapies for breast cancer. Journal of Hematology & Oncology201710:98.DOI: 10.1186/s13045-017-0466-3

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2018-01-29 minlingfeng

#Oncol#

34 0
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2017-05-23 绛珠草小姐

学习了，谢谢

67 0
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2017-05-19 大爰

学习了增加知识了分享了谢谢！

64 0
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2017-05-16 卡圣

学习了，谢谢

71 0
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2017-05-16 Docror.Xu

不知道的问题太多了

70 0
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2017-05-16 1249842em09(暂无昵称)

#转移性#

25 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 15 22:59:46 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198264, encodeId=3d1b1982643c, content=好文，值得点赞！认真学习，丰富自己。谢谢分享给广大同行！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 15 08:16:32 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198216, encodeId=f55d19821628, content=好文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon May 15 06:46:37 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
2017-05-16 fengyi812

#EMA#

27 0
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Mon May 15 22:59:46 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198264, encodeId=3d1b1982643c, content=好文，值得点赞！认真学习，丰富自己。谢谢分享给广大同行！, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon May 15 08:16:32 CST 2017, time=2017-05-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=198216, encodeId=f55d19821628, content=好文章，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon May 15 06:46:37 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
2017-05-15 131****2916

还不错的文章，值得看(⊙o⊙)

58 0
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon May 15 06:46:37 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
2017-05-15 ylzr123

好文，值得点赞！认真学习，丰富自己。谢谢分享给广大同行！

21 0
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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Mon May 15 06:46:37 CST 2017, time=2017-05-15, status=1, ipAttribution=)]
2017-05-15 135****7952平儿

好文章，学习了

24 0