Diabetes Care:糖化血红蛋白变异预测老年2型糖尿病患者抑郁症状!

2017-06-21 xing.T MedSci原创

由此可见,血糖控制的变异与更多的抑郁症状相关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一研究文章,该研究旨在分析糖化血红蛋白(HbA1c)多年变化与随后的抑郁症状之间的关系。

该研究的受试者(n=837)是来自于以色列糖尿病和认知能力下降(IDCD)研究的参与者,研究人员旨在探讨长期2型糖尿病与认知能力下降之间的关系。所有相关的糖尿病登记册建立于1998年,其中包含了每个受试者18次糖化血红蛋白测量的平均值。这里给出的结果是基于IDCD的基线检查。抑郁症的症状是采用15项老年抑郁量表(GDS)版本来进行评估。为了量化控制血糖变异性(HbA1c测量的标准差[HbA1c-SD])与自1998年IDCD研究基线抑郁症状的数量, 通过负二项式回归模型估计了发病率比(IRRs)和相应的95%可信区间,并计算了GDS评分差。

受试者平均年龄为72.74岁(SD为4.63岁),在糖尿病登记中心的平均年份为8.7年(SD为2.64年)。平均GDS评分为2.16(SD为2.26);10%的受试者GDS评分≥6,临床显著抑郁症的截断值。平均HbA1c与HbA1c-SD显著相关(r=0.6625,p<0.0001)。HbA1c的SD,而不是平均值与随后的抑郁症状的数量显著相关。对于HbA1c-SD每增加1%,抑郁症状的数量增加了1.31个因子(IRR=1.31(95%CI为1.03-1.67);P=0.03)。

由此可见,血糖控制的变异与更多的抑郁症状相关。

原始出处:

Ramit Ravona-Springer,et al. Hemoglobin A1c Variability Predicts Symptoms of Depression in Elderly Individuals With Type 2 Diabetes.Diabetes Care 2017 Jun; dc170204.https://doi.org/10.2337/dc16-2754

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    2017-06-21 清风拂面

    谢谢分享,学习了,

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