Int J Mol Sci:氧化石墨烯修饰骨水泥可更好的发挥抗感染作用

2019-06-21 不详 网络

丙烯酸骨水泥(ABCs)在骨科手术中起关键作用,主要在关节成形术中,但它们的使用越来越多地扩展到其他应用,例如癌骨重塑,颅骨成形术和椎体成形术。然而,这些材料存在与其惰性行为和植入后感染风险相关的一些缺陷。在这项研究中,研究人员探究了壳聚糖(CS)和氧化石墨烯(GO)修饰的ABCs的物理化学,热学,机械和生物学性质。傅立叶变换红外(FTIR)光谱,质子核磁共振(1H-NMR)扫描电子显微镜(SEM

丙烯酸骨水泥(ABCs)在骨科手术中起关键作用,主要在关节成形术中,但它们的使用越来越多地扩展到其他应用,例如癌骨重塑,颅骨成形术和椎体成形术。然而,这些材料存在与其惰性行为和植入后感染风险相关的一些缺陷。在这项研究中,研究人员探究了壳聚糖(CS)和氧化石墨烯(GO)修饰的ABCs的物理化学,热学,机械和生物学性质。

傅立叶变换红外(FTIR)光谱,质子核磁共振(1H-NMR)扫描电子显微镜(SEM),拉曼映射,热重分析(TGA),差示扫描量热法(DSC),抗压缩性,机械动力学分析(DMA),水解降解,细胞活力,碱性磷酸酶(ALP)活性与人成骨细胞(HOb)和抗革兰氏阴性细菌的抗菌活性大肠杆菌用于表征ABCs。

结果显示GO纳米片在ABCs中的良好分散。GO提供了抗菌活性,粗糙度和弯曲行为的增加,而CS产生了孔隙率,降低了降解速率,并降低了压缩性能。所有ABCs都没有细胞毒性,并且支持HOb良好的细胞活力。同时含有GO和CS的ABCs的新配方提高了热稳定性,弯曲模量,抗菌行为和成骨活性,这使其在整形外科应用中具有很高的应用潜力。

原始出处:

Valencia Zapata ME, Mina Hernandez JH, et al., Novel Bioactive and Antibacterial Acrylic Bone Cement Nanocomposites Modified with Graphene Oxide and Chitosan. Int J Mol Sci. 2019 Jun 15;20(12). pii: E2938. doi: 10.3390/ijms20122938.

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    2019-06-23 zhs3882
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    2019-06-23 zhangyxzsh