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Obstet Gynecol：胎膜破裂后采用Foley导管加催产素与单纯催产素疗效比较！

2017-12-26 xing.T MedSci原创

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由此可见，在分娩前膜破裂的患者中，使用经宫颈Foley导管时增加催产素与单独使用缩宫素相比并未缩短分娩时间，但可能增加了羊膜内感染的发生率。

近日，妇产科权威杂志Obstetrics and Gynecology上发表了一研究文章，研究人员旨在评估使用经宫颈Foley导管加催产素输液与单独使用催产素输液相比用于妊娠34周或以上的胎膜早破孕妇诱发产程和宫颈成熟上的疗效。

这是一项随机、多中心的试验，研究对象为妊娠34周或以上单胎、胎膜早破、宫颈检查结果不良（不到2厘米）和无分娩禁忌症的妊娠妇女。参与者被随机分配到充满30cc的经宫颈Foley导管同时使用催产素输注组或单独使用催产素输注组。催产素治疗在各个区域进行标准化。该研究的主要结局是从引产到分娩的时间间隔。为了检测到从引产到分娩间隔2.5小时的差异，研究人员获取了194名妇女的结局数据，假设效能为80％和双尾α为5％。根据意向治疗进行分析。

研究人员招募了201名女性：93名被分配到Foley组，108名被分配到单纯催产素组。各组之间的人口统计学指标相似。组间分娩时间无显著差异：Foley组为13.9小时（±6.9 SD），而催产素组为14.4小时（±7.9 SD）（P=0.69）。与催产素组相比，Foley组的临床绒毛膜羊膜炎病例更多（8％ vs. 0％，P<0.01）。其他感染性疾病或其他研究变量没有差异。

由此可见，在分娩前膜破裂的患者中，使用经宫颈Foley导管时增加催产素与单独使用缩宫素相比并未缩短分娩时间，但可能增加了羊膜内感染的发生率。

原始出处：

Mackeen A. Dhanya, et al.Foley Plus Oxytocin Compared With Oxytocin for Induction After Membrane Rupture: A Randomized Controlled Trial. Obstetrics & Gynecology.2017. http://journals.lww.com/greenjournal/Fulltext/2018/01000/Intrauterine_Balloon_Tamponade_for_Severe.21.aspx

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    2018-07-14 1249842em09(暂无昵称)

    #NEC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2044030, encodeId=a71020440302f, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jul 14 01:12:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011360, encodeId=38c120113601e, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sun Dec 02 19:12:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529937, encodeId=0677152993ecd, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Thu Dec 28 10:12:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272765, encodeId=5c0a2e276557, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Dec 26 21:47:07 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2018-12-02 yhy100200

    #TET#

    0

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    2017-12-28 zhanfl

    #催产#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2044030, encodeId=a71020440302f, content=<a href='/topic/show?id=8513126129d' target=_blank style='color:#2F92EE;'>#NEC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12612, encryptionId=8513126129d, topicName=NEC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1ac22500003, createdName=1249842em09(暂无昵称), createdTime=Sat Jul 14 01:12:00 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2011360, encodeId=38c120113601e, content=<a href='/topic/show?id=840d1e300e5' target=_blank style='color:#2F92EE;'>#TET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17300, encryptionId=840d1e300e5, topicName=TET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cc52251, createdName=yhy100200, createdTime=Sun Dec 02 19:12:00 CST 2018, time=2018-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1529937, encodeId=0677152993ecd, content=<a href='/topic/show?id=010228026b8' target=_blank style='color:#2F92EE;'>#催产#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28026, encryptionId=010228026b8, topicName=催产)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9f1711981795, createdName=zhanfl, createdTime=Thu Dec 28 10:12:00 CST 2017, time=2017-12-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272765, encodeId=5c0a2e276557, content=好资料学习了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=92191944782, createdName=thlabcde, createdTime=Tue Dec 26 21:47:07 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-26 thlabcde

    好资料学习了!

    0