Sci Rep：西兰花，又一项功效将被证实！

2017-08-10 MedSci MedSci原创

骨关节炎是造成人残疾的主要原因，目前还没有可以预防或减慢疾病进展的药物。饮食建议或补充因其毒性低且易于实施管理而成为治疗该疾病的一个很有吸引力的选择。本实验组既往研究已经证明，西兰花中的萝卜硫素——一种来自其芥子油苷前体的膳食异硫氰酸酯，在体外和体内的骨关节炎模型中均发现萝卜硫素可预防细胞中的软骨破坏。本研究将延续上一个研究结果，研究人员选择了40例接受全膝关节置换术的膝关节骨关节炎患者进行此验证

骨关节炎是造成人残疾的主要原因，目前还没有可以预防或减慢疾病进展的药物。饮食建议或补充因其毒性低且易于实施管理而成为治疗该疾病的一个很有吸引力的选择。本实验组既往研究已经证明，西兰花中的萝卜硫素——一种来自其芥子油苷前体的膳食异硫氰酸酯，在体外和体内的骨关节炎模型中均发现萝卜硫素可预防细胞中的软骨破坏。

本研究将延续上一个研究结果，研究人员选择了40例接受全膝关节置换术的膝关节骨关节炎患者进行此验证试验。术前随机将患者分为低或高硫代葡萄糖苷饮食组，干预处理14天。

结果显示，高硫代葡萄糖苷酸饮食组患者的关节滑液中检测到异硫氰酸酯，而低硫代葡萄糖苷酸饮食组则未检测到。表明患者体内血浆中异硫氰酸酯的水平升高，特别是萝卜硫烷。关节滑液蛋白质组学分析显示，两组患者关节滑液内有125个蛋白质表达存在明显差异。

总之，该研究结果表明，萝卜硫素或可影响骨关节炎患者的临床结局，本实验中所发现的功能性作用也将在一项临床试验中进行测试。

原始出处：

Rose Davidson, Sarah Gardner, et al., Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint. Sci Rep. 2017; 7: 3398.Published online 2017 Jun 13. doi: 10.1038/s41598-017-03629-5.

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#插入话题

插入图片

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2017-08-12 smallant2004

#西兰花#

53 0
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2017-08-11 flyingzyx

多吃一些

84 0
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2017-08-11 jet747

又要多吃西兰花了？

64 0
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2017-08-11 yfjms

学习了

87 0
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2017-08-10 189****7206

学习了受益匪浅

82 0
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2017-08-10 yfjms

学习了

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