JAHA:经导管主动脉瓣植入心肌血运重建的生理vs.血管造影引导

2019-11-29 xiangting MedSci原创

在这项观察性研究中,FFR引导与经导管主动脉瓣植入患者较好的预后相关。

经导管主动脉瓣植入患者冠脉疾病的治疗尚不明确。主动脉瓣狭窄的血流储备分数(FFR)尚未得到临床验证。这项研究目的是分析经导管主动脉瓣植入患者FFR引导血运重建的临床结局。

这项回顾性分析纳入冠脉造影有冠脉疾病的严重主动脉瓣狭窄患者,并分为两组:血管造影引导(122/21656.5%)vs FFR引导血运重建(94/21643.5%)。对患者进行临床随访,并在2年随访时评估主要不良心脏和脑血管事件的发生率。根据常规的0.80阈值,FFR组的大多数病变结果为阴性(111/14278.2%),并被推迟。FFR引导组无主要不良心脏和脑血管事件生存率优于血管引导组(92.6vs 82.0%;危险比,0.4 95 CI0.2–1.0; P0.035)。根据FFR病变延迟患者的预后优于血管引导PCI患者(91.4vs 68.1%;危险比为0.3 95 CI0.1–0.6; P 0.001)。

在这项观察性研究中,FFR引导与经导管主动脉瓣植入患者较好的预后相关。需要随机试验来研究主动脉瓣狭窄患者FFR引导血运重建与仅血管造影引导的长期影响。

原始出处:

Mattia Lunardi. Physiological Versus Angiographic Guidance for Myocardial Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation. JAHA. 13 Nov 2019.

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    2019-12-01 zhaohui6731
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    2019-12-01 sodoo
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    2019-12-01 lsj631
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    2019-12-01 jiyangfei

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