Gut:一般人群恶性结直肠息肉内镜切除的结局与手术切除相似!

2017-10-27 xing.T MedSci原创

在一般人群对于息肉病理切缘≥1mm的患者内镜下切除的结局与那些手术切除的患者相似。对于病理切缘小于1mm的内镜下切除无法完成需要通过手术完成。

以人群为基础的结直肠恶性息肉(MPs)研究很少。近日,消化病领域权威杂志Gut上发表了一篇研究文章,该研究的目的是描述结直肠肿块筛查方案2003开始前后MPs发生率的时间趋势,并且评估MPs患者经内镜或手术切除后的结局(生存和复发)。

研究人员纳入了411名在1982年至2011年期间明确诊断的MPs患者,并且计算了年龄标准化的发病率。根据大体形态进行单变量和多变量5年复发率和净生存率分析。

研究人员发现50-74岁的患者MPs的年龄标准化发病率翻了一番,从1982年至2002年期间的5.4上升到2003年至2011年期间的10.9例每100000人。带蒂MPs更频繁地进行内镜下切除(38.2%)相比于无柄的MPs(19.1%;P<0.001)。对于带蒂MPs和病理切缘≥1mm的患者,5 年累积复发率在手术切除和内镜下切除之间没有显著差异(分别为8.2%和2.4%)。对于无柄MPs患者,3%的患者进行一线或二线手术切除,8.6%在内镜下切除和17.9%经肛门切除(P=0.016)。对于无柄MPs患者,复发率显著降低,从1982年至2002年期间的11.3%下降到2003年至2009年期间的1.2%(P=0.010),而对于带蒂MPs患者保持稳定分别为4.6%和6.7%。病理切缘<1mm的患者五年净生存率为81%,病理切缘≥1mm的患者则为95.6%(P=0.024)。

由此可见,在一般人群对于息肉病理切缘≥1mm的患者内镜下切除的结局与那些手术切除的患者相似。对于病理切缘小于1mm的内镜下切除无法完成需要通过手术完成。

原始出处:


Anthony Lopez,et al. Outcomes following polypectomy for malignant colorectal polyps are similar to those following surgery in the general population. Gut. 2017. http://dx.doi.org/10.1136/gutjnl-2016-312093

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    2018-01-15 祝您健康

    学习很重要

    0

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    2017-11-03 大爰

    学习了谢谢分享!!

    0

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    2017-10-29 docwu2019
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    2017-10-28 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=278727, encodeId=3aed2e8727a0, content=学习很重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/22/005b55a98a8b2e8ec8bd5577813de704.jpg, createdBy=29fc2176768, createdName=祝您健康, createdTime=Mon Jan 15 13:21:14 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=258302, encodeId=6d4f2583027e, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Nov 03 09:18:46 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1261938, encodeId=85b0126193860, content=<a href='/topic/show?id=0ceb30545e0' target=_blank style='color:#2F92EE;'>#内镜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30545, encryptionId=0ceb30545e0, topicName=内镜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sun Oct 29 03:46:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429412, encodeId=5d1f14294123f, content=<a href='/topic/show?id=bb015438221' target=_blank style='color:#2F92EE;'>#手术切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54382, encryptionId=bb015438221, topicName=手术切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cfdd4195665, createdName=s_pl2009, createdTime=Sun Oct 29 03:46:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1452996, encodeId=0ffb1452996e6, content=<a href='/topic/show?id=098ee8679ad' target=_blank style='color:#2F92EE;'>#结直肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78679, encryptionId=098ee8679ad, topicName=结直肠)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9ace5575596, createdName=crystal0564, createdTime=Sun Oct 29 03:46:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1486745, encodeId=73581486e45db, content=<a href='/topic/show?id=b1d8e868430' target=_blank style='color:#2F92EE;'>#结直肠息肉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78684, encryptionId=b1d8e868430, topicName=结直肠息肉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=066c8204452, createdName=neurowu, createdTime=Sun Oct 29 03:46:00 CST 2017, time=2017-10-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256642, encodeId=490025664272, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Oct 28 11:08:39 CST 2017, time=2017-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=256401, encodeId=8a362564016e, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri Oct 27 13:31:22 CST 2017, time=2017-10-27, status=1, ipAttribution=)]
    2017-10-27 清风拂面

    谢谢分享.学习了

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