Am J Obstet Gynecol:关于妊娠女性感染HCV的筛查、治疗和管理指南。

2017-08-04 MedSci MedSci原创

母胎医学关于筛查、治疗和管理孕期HCV感染的指南。

科普:丙型病毒性肝炎,简称为丙型肝炎、丙肝,是一种由丙型肝炎病毒(HCV)感染引起的病毒性肝炎,主要经输血、针刺、吸毒、母婴等传播。

在美国,有1-2.5%的妊娠妇女感染丙型肝炎病毒(HCV),大约5%会发生母胎传播。HCV可以在子宫内或分娩期传染给胎儿,妊娠期间胎儿感染HCV会增加不良预后的风险,如胎儿生长受限和低出生体重儿。

母胎医学关于筛查、治疗和管理孕期HCV感染的指南:(1)产科保健工作者应该在HCV感染高危的女性第一次产检时为其检测抗HCV抗体。如果首次检验阴性,随后高危因素持续存在或新出现风险因素则应重复检验。(2)对于HCV阳性的妊娠妇女,保健工作者应继续为其检测其他性传播疾病,包括HIV、梅毒、淋病、衣原体和HBV(GRADE 1B);(3)推荐HCV感染者,包括妊娠女性,应戒酒;(4)在临床试验或抗病毒治疗中使用的直接作用的抗病毒药物(DAA)方案,应推迟到产后阶段,因为目前尚没有批准用于妊娠妇女的DAA方案(GRADE 1C);(5)如果需要有创性产前诊断,应向其科普母婴传播的风险数据虽然尚可但有限,推荐绒毛膜羊膜腔穿刺术(GRADE 2C);(6)反对仅因为HCV感染而采取剖腹产(GRADE 1B);(7)尽量避免对HCV阳性的妊娠妇女行宫内胎儿检测、延长胎膜破裂的时间以及分娩过程中行外阴切开术(GRADE 1B);(8)HCV阳性的女性也可以哺乳,不建议仅因为HCV阳性而放弃哺乳(GRADE 1A)。

原始出处:

Brenna L.Hughes,Charlotte M.Page,Jeffrey A.Kuller.Society for Maternal-Fetal Medicine (SMFM) Consult Series #43: Hepatitis C in Pregnancy: Screening, Treatment and Management.Am J Obstet gynecol.August 03,2017.http://dx.doi.org/10.1016/j.ajog.2017.07.039

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    2018-06-26 yhy100200
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    2017-08-06 ymljack
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    2017-08-04 清风拂面

    学习了,谢谢分享

    0

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