SCI REP:乳腺癌妇女血清TFF1和TFF3升高!

2017-07-08 xing.T MedSci原创

由此可见,患有乳腺癌的妇女血清中TFF1和TFF3浓度较没有乳腺癌的妇女要高,但TFF2并不升高。

乳腺癌仍然是女性常见的恶性肿瘤,但在日本,乳腺癌筛查项目的利用率仍然很低,这可能是由于它的不便所造成的。TFF1和TFF3表达在乳腺癌组织和正常乳腺组织中。血清三叶蛋白被报道作为胃、前列腺、肺、胰腺癌和胆管癌等癌症筛查标志物。近日,Scientific reports 杂志上发表了一篇荟萃分析文章,该研究旨在评估血清三叶草蛋白是否可作为乳腺癌的生物标志物。

研究人员采用ELISA法检测94例乳腺癌患者和84例健康体检妇女血清中三叶草蛋白含量。研究人员发现乳腺癌患者血清中TFF1和TFF3水平明显增高,血清中TFF2水平显著降低。并且TFF1、TFF2和TFF3接受者操作特征曲线下面积分别为0.69、0.83和0.72。TFF1、TFF2和TFF3组合的AUC为0.96。

通过免疫组化实验,发现56.5%的乳腺癌患者TFF1表达阳性,73.9%的乳腺癌患者TFF3表达阳性,而在所有肿瘤中TFF2表达为阴性。血清TFF1与乳腺癌组织中TFF1表达呈正相关。

由此可见,患有乳腺癌的妇女血清中TFF1和TFF3浓度较没有乳腺癌的妇女要高,但TFF2并不升高。

原始出处:

Yuko Ishibashi,et al. Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-05129-y

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    2017-07-10 jyzxjiangqin

    乳腺癌妇女血清变化。

    0

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    2017-07-09 flysky120

    为什么癌症发病率高呢

    0

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    2017-07-09 飛歌

    研究很前瞻啊bucuo

    0

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    2017-07-08 luominglian113

    学习了,谢谢分享

    0

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    2017-07-08 三生有幸9135

    学习一下谢谢分享

    0

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    2017-07-08 Y—xianghai

    学习了新知识

    0

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    2017-07-08 执着追梦

    学习,谢谢分享

    0

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    2017-07-08 1861f3644em

    学习了,谢谢

    0

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    2017-07-08 Drhzm308

    学习了,谢谢

    0

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