Heart:严重主动脉瓣狭窄患者主动脉瓣置换后的左心室充盈压和生存率

2020-03-28 xiangting MedSci原创

接受AVR的AS患者术前左心室充盈压升高是常见现象,无论其症状如何,均具有重要的预后意义。

这项研究旨在确定超声心动图检查获得的左心室充盈压是否会影响接受主动脉瓣置换(AVR)严重主动脉瓣狭窄(AS)患者的生存率。

研究回顾性分析了1383例连续性严重AS患者,这些患者接受AVR治疗且射血分数正常有可解释的充盈压。根据当前指南使用二尖瓣流入量、二尖瓣环形组织多普勒、估算的右心室收缩压和左心房容积指数确定左心室充盈压。使用Cox比例风险回归来评估各种指标对死亡率的影响。

年龄为75±10岁,女性552例(40%)。325例患者的左心室充盈压正常(23%),463例不确定(33%),595例升高(43%)。平均随访7.3±3.7年,30天、1年和5年死亡率分别为1.2%、4.2%和18.9%。与正常充盈压患者相比,充盈压升高患者的年龄更大(78±9 vs 70±12,p<0.001),女性更多(45%vs 35%,p=0.002),并且更可能有NYHA III-IV级症状(35%vs 24%,p=0.004)、冠心病(55%vs 42%,p<0.001)和同心左心室肥大(63%vs 37%,p<0.001)。校正其他因素后,左心室充盈压升高仍是成功AVR后死亡率的独立预测因素(调整HR 1.45(95%CI 1.16-1.81),p=0.005)。

接受AVR的AS患者术前左心室充盈压升高是常见现象,无论其症状如何,均具有重要的预后意义。未来的前瞻性研究应考虑到充盈压升高患者是否能从早期手术中受益。

原始出处:

Jeremy J Thaden. Left ventricular filling pressure and survival following aortic valve replacement for severe aortic stenosis. Heart. March 2020.

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    2020-08-01 yxch48
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    2020-03-30 zhaojie88
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    2020-03-30 slcumt

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