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2011年诺贝尔生理学或医学奖新鲜出炉

2011-10-03 MedSci原创 MedSci原创

诺贝尔生理学或医学
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      北京时间10月3日17点30分，2011年诺贝尔生理学或医学奖揭晓，美国的Bruce A. Beutler、卢森堡的Jules A. Hoffmann以及加拿大的Jules A. Hoffmann三位科学家因在免疫学方面的发现获奖。其中一半的奖金归于Bruce A. Beutler and Jules A. Hoffmann，获奖理由是“先天免疫激活方面的

      北京时间10月3日17点30分，2011年诺贝尔生理学或医学奖揭晓，美国的Bruce A. Beutler、卢森堡的Jules A. Hoffmann以及加拿大的Jules A. Hoffmann三位科学家因在免疫学方面的发现获奖。其中一半的奖金归于Bruce A. Beutler and Jules A. Hoffmann，获奖理由是“先天免疫激活方面的发现”；另一半奖金归于Ralph M. Steinman，获奖理由是“发现树枝状细胞及其在获得性免疫中的作用”。

       今年的诺奖得主发现了免疫系统活化的关键原理，从而彻底革新了我们对免疫系统的认识。
 
       免疫应答作为一种能帮助人类与其它动物抵御细菌及其它微生物的生理过程，长久以来，科学家们一直在寻找它的“守护者”。Bruce Beutler和Jules Hoffmann发现了能识别微生物并激活天然免疫的受体蛋白质，从而揭示了身体免疫应答过程的第一步。Ralph Steinman则发现了免疫系统中的树突状细胞，以及其可激活并控制适应性免疫的功能，从而完成身体免疫应答过程的下一步，即将微生物清除出体内。
 
       三位诺奖得主的发现揭示了免疫应答中的先天性免疫和适应性免疫是如何被激活，从而让我们对疾病机理有了一个新的见解。他们的工作为传染病、癌症以及炎症的防治开辟了新的道路。

https://img.medsci.cn/webeditor/uploadfile/201110/20111003215302710.jpg
Bruce A. Beutler
       Bruce A. Beutler，1957年出生于美国芝加哥。1981年从芝加哥大学获得医学博士学位。曾在洛克菲勒大学和德州大学工作，其间发现了LPS受体。自2000年开始，他是斯科利普斯研究所遗传学和免疫学教授。（详细介绍）,他实验室主页: http://www.scripps.edu/genetics/beutler/   
 
https://img.medsci.cn/webeditor/uploadfile/201110/20111003215305203.jpg
Jules A. Hoffmann
       Jules A. Hoffmann，1941年出生于卢森堡公国。就读于法国斯特拉斯堡大学，1969年获得博士学位。在德国马尔堡大学做完博士后之后，他返回了斯特拉斯堡 2007年-2008年他曾担任斯特拉斯堡分子细胞生物学研究所所长。 （详细介绍）,他实验室主页: http://www-ibmc.u-strasbg.fr/ridi/profil.php?equipe_id=10

https://img.medsci.cn/webeditor/uploadfile/201110/20111003215307434.gif
Ralph M. Steinman
       Ralph M. Steinman，1943年出生于加拿大蒙特利尔。在麦吉尔大学学习生物学和化学。1968年从哈佛医学院获得医学博士学位。自1970年开始他一直在洛克菲勒大学工作， 1988年开始成为免疫学教授，并担任免疫学和免疫疾病中心主任。 （详细介绍）,其实验室主页: http://www.rockefeller.edu/research/faculty/labheads/RalphSteinman/  
 
MedSci评:这一发现，也为急功近利者敲响警钟，大家都认为这几年比较火的IPS细胞可能会获奖，但是最终证明，诺贝尔奖是需要时间沉淀的，科学同样如此。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1752744, encodeId=4d231e52744d0, content=<a href='/topic/show?id=09736951388' target=_blank style='color:#2F92EE;'>#生理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69513, encryptionId=09736951388, topicName=生理学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b3136571640, createdName=chenzhuanggui, createdTime=Tue Jul 17 11:44:00 CST 2012, time=2012-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1942334, encodeId=e2921942334ef, content=<a href='/topic/show?id=17c791954bf' target=_blank style='color:#2F92EE;'>#诺贝尔生理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91954, encryptionId=17c791954bf, topicName=诺贝尔生理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Fri Apr 13 07:44:00 CST 2012, time=2012-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066913, encodeId=dcd8206691321, content=<a href='/topic/show?id=0f8b6951667' target=_blank style='color:#2F92EE;'>#生理学或医学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69516, encryptionId=0f8b6951667, topicName=生理学或医学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Fri Apr 27 23:44:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967693, encodeId=3a46196e69397, content=<a href='/topic/show?id=3a1c6951e55' target=_blank style='color:#2F92EE;'>#生理学或医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69517, encryptionId=3a1c6951e55, topicName=生理学或医学奖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Aug 15 17:44:00 CST 2012, time=2012-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537374, encodeId=1eca153e3749e, content=<a href='/topic/show?id=47e09195633' target=_blank style='color:#2F92EE;'>#诺贝尔生理学或医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91956, encryptionId=47e09195633, topicName=诺贝尔生理学或医学奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1d12859536, createdName=yangpeizhi, createdTime=Wed Oct 05 12:44:00 CST 2011, time=2011-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543439, encodeId=3f7b15434399a, content=<a href='/topic/show?id=274e340e5fd' target=_blank style='color:#2F92EE;'>#医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=34075, encryptionId=274e340e5fd, topicName=医学奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250d13588803, createdName=斯嘉莉, createdTime=Wed Oct 05 12:44:00 CST 2011, time=2011-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3230, encodeId=c324323013, content=谢谢, 介绍得相当详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=lifesci, createdTime=Mon Oct 03 22:16:00 CST 2011, time=2011-10-03, status=1, ipAttribution=)]
    2012-07-17 chenzhuanggui

    #生理学#

    0

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    2012-04-13 cqlidoudou

    #诺贝尔生理学#

    0

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    2012-04-27 小小小向日葵

    #生理学或医学#

    0

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    2012-08-15 lxg951

    #生理学或医学奖#

    0

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    2011-10-05 yangpeizhi

    #诺贝尔生理学或医学奖#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1752744, encodeId=4d231e52744d0, content=<a href='/topic/show?id=09736951388' target=_blank style='color:#2F92EE;'>#生理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69513, encryptionId=09736951388, topicName=生理学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b3136571640, createdName=chenzhuanggui, createdTime=Tue Jul 17 11:44:00 CST 2012, time=2012-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1942334, encodeId=e2921942334ef, content=<a href='/topic/show?id=17c791954bf' target=_blank style='color:#2F92EE;'>#诺贝尔生理学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91954, encryptionId=17c791954bf, topicName=诺贝尔生理学)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Fri Apr 13 07:44:00 CST 2012, time=2012-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066913, encodeId=dcd8206691321, content=<a href='/topic/show?id=0f8b6951667' target=_blank style='color:#2F92EE;'>#生理学或医学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69516, encryptionId=0f8b6951667, topicName=生理学或医学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Fri Apr 27 23:44:00 CST 2012, time=2012-04-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1967693, encodeId=3a46196e69397, content=<a href='/topic/show?id=3a1c6951e55' target=_blank style='color:#2F92EE;'>#生理学或医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69517, encryptionId=3a1c6951e55, topicName=生理学或医学奖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Wed Aug 15 17:44:00 CST 2012, time=2012-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1537374, encodeId=1eca153e3749e, content=<a href='/topic/show?id=47e09195633' target=_blank style='color:#2F92EE;'>#诺贝尔生理学或医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91956, encryptionId=47e09195633, topicName=诺贝尔生理学或医学奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7e1d12859536, createdName=yangpeizhi, createdTime=Wed Oct 05 12:44:00 CST 2011, time=2011-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543439, encodeId=3f7b15434399a, content=<a href='/topic/show?id=274e340e5fd' target=_blank style='color:#2F92EE;'>#医学奖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=34075, encryptionId=274e340e5fd, topicName=医学奖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=250d13588803, createdName=斯嘉莉, createdTime=Wed Oct 05 12:44:00 CST 2011, time=2011-10-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=3230, encodeId=c324323013, content=谢谢, 介绍得相当详细, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=lifesci, createdTime=Mon Oct 03 22:16:00 CST 2011, time=2011-10-03, status=1, ipAttribution=)]
    2011-10-05 斯嘉莉

    #医学奖#

    0

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    2011-10-03 lifesci

    谢谢, 介绍得相当详细

    0

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