Prostate Cancer P D :基线前列腺萎缩与更小的肿瘤体积相关

2017-12-15 AlexYang MedSci原创

前列腺萎缩(PA)在前列腺生物活检中经常遇到。之前的研究表明了PA也许与更低的PCa风险相关。然而,是否PA与更小的、更不具有侵入性的和更低程度晚期肿瘤相关仍旧未知。因此,研究人员探究了是否在最初前列腺(PCa)活检阴性的男性中,基线PA的存在和严重度与PCa体积在第2年和第4年重复活检相关。研究人员在927名年龄在50-75岁男性且具有阴性PCa基线活检和2年和4年后重复PCa活检阳性的群体中进

前列腺萎缩(PA)在前列腺生物活检中经常遇到。之前的研究表明了PA也许与更低的PCa风险相关。然而,是否PA与更小的、更不具有侵入性的和更低程度晚期肿瘤相关仍旧未知。因此,研究人员探究了是否在最初前列腺(PCa)活检阴性的男性中,基线PA的存在和严重度与PCa体积在第2年和第4年重复活检相关。

研究人员在927名年龄在50-75岁男性且具有阴性PCa基线活检和2年和4年后重复PCa活检阳性的群体中进行了回顾性的研究。研究发现,在559名(60%)男性的基线活检中鉴定到了PA,其中491(88%)名为轻度,68名(12%)为中度/明显。PA与更大的前列腺体积相关(P<0.001)。在第2年的活检中,PA与更低的总平均肿瘤体积(2.21 vs. 2.94mL; P=0.016),活组织检查涉及核的平均数目(1.85 vs. 2.08; P=0.016 ),涉及核的平均比例(18.4% vs. 20.7%; P=0.008),平均核心参与(0.23 vs. 0.29mL; P=0.019)和总的平均肿瘤参与比例(1.82% vs. 2.33%; P=0.018)相关。另外,研究人员在多变量分析和第4年重复活检中发现的相似的结果。与轻度PA相比,中度/明显的PA与肿瘤体积更大的减少相关。最后,研究人员指出,PCa基线活检阴性且随后重复前列腺活检阳性的的患者中,基线PA的存在和严重度与更低的PCa体积相关。这也表明了PA也许与PCa更低侵入性相关。

原始出处:

Daniel M. Moreira, Gerald L. Andriole, Ramiro Castro-Santamaria et al. Baseline prostate atrophy is associated with lower tumor volume in men with prostate cancer on repeat biopsy. Prostate Cancer P D. 04 Dec 2017.

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    2018-06-09 chendoc252
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    2017-12-17 lsndxfj
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    2017-12-17 sunylz
  5. [GetPortalCommentsPageByObjectIdResponse(id=1791521, encodeId=5aa01e9152195, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 17 06:06:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695829, encodeId=685f169582940, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Sat Jun 09 21:06:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364267, encodeId=4708136426e18, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601949, encodeId=0180160194960, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269855, encodeId=158826985548, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sat Dec 16 13:38:54 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269852, encodeId=2fea26985271, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEL1lbeB4KXPkoejHWBRHudEaddxiaBQDGcgEsNibh974wniaAEJAYLAC6fddUD5MmvECdAOmMjNWbPibg/132, createdBy=57332207937, createdName=Fiona_rj, createdTime=Sat Dec 16 13:10:11 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269845, encodeId=1d2c269845aa, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:48:41 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 九九消寒

    优质资源.共同学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1791521, encodeId=5aa01e9152195, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 17 06:06:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695829, encodeId=685f169582940, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Sat Jun 09 21:06:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364267, encodeId=4708136426e18, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601949, encodeId=0180160194960, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269855, encodeId=158826985548, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sat Dec 16 13:38:54 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269852, encodeId=2fea26985271, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEL1lbeB4KXPkoejHWBRHudEaddxiaBQDGcgEsNibh974wniaAEJAYLAC6fddUD5MmvECdAOmMjNWbPibg/132, createdBy=57332207937, createdName=Fiona_rj, createdTime=Sat Dec 16 13:10:11 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269845, encodeId=1d2c269845aa, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:48:41 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 Fiona_rj

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1791521, encodeId=5aa01e9152195, content=<a href='/topic/show?id=b77f14e4541' target=_blank style='color:#2F92EE;'>#Prostate Ca#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14745, encryptionId=b77f14e4541, topicName=Prostate Ca)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jan 17 06:06:00 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1695829, encodeId=685f169582940, content=<a href='/topic/show?id=03b98809697' target=_blank style='color:#2F92EE;'>#萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88096, encryptionId=03b98809697, topicName=萎缩)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=53fc29868494, createdName=chendoc252, createdTime=Sat Jun 09 21:06:00 CST 2018, time=2018-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364267, encodeId=4708136426e18, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601949, encodeId=0180160194960, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Sun Dec 17 12:06:00 CST 2017, time=2017-12-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269855, encodeId=158826985548, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sat Dec 16 13:38:54 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269852, encodeId=2fea26985271, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/PiajxSqBRaEL1lbeB4KXPkoejHWBRHudEaddxiaBQDGcgEsNibh974wniaAEJAYLAC6fddUD5MmvECdAOmMjNWbPibg/132, createdBy=57332207937, createdName=Fiona_rj, createdTime=Sat Dec 16 13:10:11 CST 2017, time=2017-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269845, encodeId=1d2c269845aa, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:48:41 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0