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Lancet：多西紫杉醇3D疗法（FLOT）治疗晚期可切除胃癌

2019-04-13 MedSci MedSci原创

胃癌FLOT多西紫杉醇
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研究认为，对于局部晚期可切除的胃或胃食管交界腺癌患者，围手术期接受FLOT疗法可提高患者整体生存率

多西紫杉醇为基础的化疗是治疗转移性胃和胃食管交界癌的有效手段，近日研究人员考察了多西紫杉醇三联疗法 (FLOT，氟尿嘧啶+亚叶酸、奥沙利铂和多西紫杉醇)对局部晚期可切除肿瘤患者围手术期治疗的效果。

本次研究为II-III期临床研究，716名经组织学证实的晚期、临床分期CT 2或以上，和或淋巴结阳性(CN+)患者参与研究，患者肿瘤可切除，无远端转移，一部分患者在术前以及术后分别接受3轮，每轮3周的表柔比星+顺铂+氟尿嘧啶或卡培他滨 (ECF/ECX；对照组)，另外的患者在术前以及术后分别接受4轮，每轮4周的FLOT治疗。研究的主要重点为总生存期。

716名患者参与研究，其中ECF/ECX组360例，FLOX组356例。与ECF/ECX组相比，FlOT组总生存率提高(HR=0.77)，中位总生存期为50 vs 35个月。两组患者发生严重不良事件(包括手术住院期间发生的不良事件)的数量相似(ECF/ECX组96例[27%]，FlOT组97例[27%])，两组各有2例中毒死亡。94例(26%)ECF/ECX患者出现毒性住院，Flot组89例(25%)。

研究认为，对于局部晚期可切除的胃或胃食管交界腺癌患者，围手术期接受FLOT疗法可提高患者整体生存率。

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    2020-01-03 zjshifan_98647306

    #FLOT#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1985160, encodeId=e290198516018, content=<a href='/topic/show?id=1e66e509f7' target=_blank style='color:#2F92EE;'>#FLOT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7509, encryptionId=1e66e509f7, topicName=FLOT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Fri Jan 03 21:03:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830023, encodeId=5a10183002359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jul 13 14:03:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336110, encodeId=5873133611061, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587289, encodeId=4ec7158e2897b, content=<a href='/topic/show?id=1bdc43456b3' target=_blank style='color:#2F92EE;'>#多西紫杉醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43456, encryptionId=1bdc43456b3, topicName=多西紫杉醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f2717457850, createdName=zhaozhouchifen, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=)]
    2019-07-13 howi

    #Lancet#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1985160, encodeId=e290198516018, content=<a href='/topic/show?id=1e66e509f7' target=_blank style='color:#2F92EE;'>#FLOT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7509, encryptionId=1e66e509f7, topicName=FLOT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Fri Jan 03 21:03:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830023, encodeId=5a10183002359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jul 13 14:03:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336110, encodeId=5873133611061, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587289, encodeId=4ec7158e2897b, content=<a href='/topic/show?id=1bdc43456b3' target=_blank style='color:#2F92EE;'>#多西紫杉醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43456, encryptionId=1bdc43456b3, topicName=多西紫杉醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f2717457850, createdName=zhaozhouchifen, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=)]
    2019-04-15 ms9833124466084992

    #3D#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1985160, encodeId=e290198516018, content=<a href='/topic/show?id=1e66e509f7' target=_blank style='color:#2F92EE;'>#FLOT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7509, encryptionId=1e66e509f7, topicName=FLOT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=99cf2500102, createdName=zjshifan_98647306, createdTime=Fri Jan 03 21:03:00 CST 2020, time=2020-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1830023, encodeId=5a10183002359, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sat Jul 13 14:03:00 CST 2019, time=2019-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1336110, encodeId=5873133611061, content=<a href='/topic/show?id=792612047e' target=_blank style='color:#2F92EE;'>#3D#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1204, encryptionId=792612047e, topicName=3D)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1587289, encodeId=4ec7158e2897b, content=<a href='/topic/show?id=1bdc43456b3' target=_blank style='color:#2F92EE;'>#多西紫杉醇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=43456, encryptionId=1bdc43456b3, topicName=多西紫杉醇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f2717457850, createdName=zhaozhouchifen, createdTime=Mon Apr 15 10:03:00 CST 2019, time=2019-04-15, status=1, ipAttribution=)]
    2019-04-15 zhaozhouchifen

    #多西紫杉醇#

    0

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