Mol Ther Nucleic Acids:外泌体介导的miR-124递送可促进缺血后的神经修复

2017-12-09 MedSci MedSci原创

研究已经证实卒中后神经发生的内在能力减弱,导致神经系统损伤的修复不足。近期研究表明多种微小RNAs(miRNAs)参与了神经重建过程,因此,靶向miRNA的递送或可用于促进卒中后的神经再生。 本研究中,研究人员发现,将外泌体蛋白溶酶体相关膜糖蛋白2b(Lamp2b)与狂犬病病毒糖蛋白(RVG)融合,然后修饰外泌体可有效地将miR-124递送至梗塞部位。载有miR-124的RVG-外泌体的全身性应用

研究已经证实卒中后神经发生的内在能力减弱,导致神经系统损伤的修复不足。近期研究表明多种微小RNAs(miRNAs)参与了神经重建过程,因此,靶向miRNA的递送或可用于促进卒中后的神经发生。

本研究中,研究人员发现,将外泌体蛋白溶酶体相关膜糖蛋白2b(Lamp2b)与狂犬病病毒糖蛋白(RVG)融合,然后修饰外泌体可有效地将miR-124递送至梗塞部位。载有miR-124的RVG-外泌体的全身性应用促进了皮层神经祖细胞获得神经元特征并可通过稳健的皮层神经发生防止缺血性损伤。

综上所述,我们的研究表明,RVG-外泌体可以用于基因药物的大脑靶向递送治疗,因此在临床应用中具有巨大的潜力。

原始出处:


Yang J, Zhang X, et al., Exosome Mediated Delivery of miR-124 Promotes Neurogenesis after Ischemia. Mol Ther Nucleic Acids. 2017 Jun 16;7:278-287. doi: 10.1016/j.omtn.2017.04.010. Epub 2017 Apr 13.

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    2018-05-23 wodejia-dayu
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    2018-05-10 xlxchina
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    2017-12-10 smallant2002
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    2017-12-09 131****1460

    学习了受益匪浅

    0

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    2017-12-09 天涯183

    非常好的文章.学习了

    0

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