Cell Metab:蹬自行车,减大肚腩!科学家首次证实骑行时骨骼肌释放出的一种细胞因子IL-6,会燃烧腹部脂肪

2019-01-27 奇点糕 奇点网

腹部肥胖不仅影响美观,还跟多种疾病相关,比如心血管疾病、癌症、痴呆等。我们之前就报道过,肚子上的赘肉会释放致癌因子,增加癌症的风险。而且,在2千万亚洲人中的调查还发现,粗腰与18种癌症风险升高有关。

腹部肥胖不仅影响美观,还跟多种疾病相关,比如血管疾病、癌症、痴呆等。我们之前就报道过,肚子上的赘肉会释放致癌因子,增加癌症的风险。而且,在2千万亚洲人中的调查还发现,粗腰与18种癌症风险升高有关。

但是,这个最可恶的腹部赘肉却又是最难减的部位之一。到底如何锻炼才能更好地减去腹部脂肪,露出你的小蛮腰或者八块腹肌呢?

最近,丹麦哥本哈根大学的Rikke Krogh-Madsen教授和Helga Ellingsgaard博士团队在人体试验中证实,通过测力自行车(类似于动感单车)进行高强度间歇有氧运动,能够有效地减去腹部脂肪。

他们还发现一种细胞因子——白细胞介素6(IL-6),在减肥过程中发挥了关键作用。如果将IL-6阻断,锻炼的效果就消失了。这或许可以解释有些人无法减肥成功的原因。这项研究发表在著名学术期刊《细胞代谢》上。

Rikke Krogh-Madsen教授

腹部脂肪之所以危害巨大,是因为它是由内脏脂肪组织堆积造成的。腹部脂肪主要存在于腹腔内,并包围着肝、肠道等器官。

运动早已就被证明能增加一些激素或细胞因子的分泌,增强脂肪的消耗,促进骨质和肌肉的合成等。比如,我们前不久刚介绍过的鸢尾素。此外,在运动时人体的骨骼肌会释放IL-6到血液中,而IL-6具有刺激脂质代谢的功能。

不过,对于减去腹部脂肪,虽然各种流传的办法五花八门,真正实际有效的却不见得有多少,也缺少切实可靠的实验证据。到底哪种方式才是最有效的,我们并不确定。

对此,Helga团队征集有大肚子的志愿者,研究了通过动感单车进行高强度间歇有氧运动减去腹部脂肪的效果。另外,由于之前在严重肥胖的病人中也发现了IL-6水平上升的现象,使得人们不是很确定IL-6的功能。所以,这次试验的另一个目的就是验证IL-6在减肥中的作用。

Helga团队设计了一个双因素对照试验。他们将腹部肥胖的志愿者按照是否进行动感单车锻炼,是否阻断IL-6(摄入IL-6抗体或安慰剂)进行1:1:1:1分组。

锻炼任务要在训练师的指导下完成。动感单车组的人被要求进行为期12周,每周3次,每次45分钟的自行车锻炼,具体的锻炼程序如下图。试验为双盲试验,药物摄入在医务人员的严格指导下进行。为了避免饮食因素的干扰,所有志愿者都被要求控制能量摄入。

锻炼程序是很严格,热身运动和高强度运动交替进行

试验完成后,研究人员对志愿者进行了体检。

在不阻断IL-6的志愿者中,不进行锻炼的人,内脏脂肪仍然在不停积累,12周平均涨了83克;而锻炼的人,内脏脂肪平均减少了142克,减少幅度达到8%。其中,效果最好的人,内脏脂肪减少了近300克。

不只有内脏脂肪减少,全身脂肪重量的变化也非常明显。不锻炼的人,全身脂肪涨了180克;而锻炼的人,全身脂肪平均减少了1041克,效果最好的人减去的脂肪超过2000克。

从这个结果来看,动感单车锻炼的效果是非常明显的,该死的肥肉确实被消耗了,尤其是腹部肥肉。

在阻断IL-6的志愿者中,不锻炼的人内脏脂肪涨了162克,全身脂肪涨了76克。而进行锻炼的人,内脏脂肪涨了136克,全身脂肪涨了229克。在阻断IL-6后,锻炼并没有起到效果。

锻炼且不阻断IL-6的人才能减少脂肪

这个试验结果表明,通过动感单车进行高强度间歇有氧运动,确实能有效减去脂肪,尤其是内脏脂肪。而锻炼的作用需要IL-6分子来介导,如果IL-6信号被阻断,那再怎么锻炼也没用了。这或许就是很多人减肥不成功的原因。

运动的减腹效果需要IL-6来介导

当然,这需要进一步的实验进行验证,检测某有些肥胖患者的IL-6信号通路是否正常。

本文作者表示,他们将继续研究IL-6在脂肪或碳水物质代谢中的作用,并探索是否可以通过注射白介素-6来减少内脏脂肪的可能。(在有明确的结果之前,大家千万不要轻举妄动,IL-6在人体中的作用很复杂,参与免疫、代谢等多个生理过程。)

对于想下决心减掉肚子、缩小腰围的人来说,动感单车应该是一个不错的选择。

而对于曾幻想驾单车浪迹天涯,如今却只能困守一室的奇点糕来说,是不是要考虑把自己快生锈的自行车推出来,擦掉车座和把手上的灰,体验一把追风少年的感觉呢?

原始出处:Anne-Sophie Wedell-Neergaard, Louise Lang Lehrskov, Regitse HjgaardChristensen, et al. Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial, Cell Metab, 27 December 2018

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    2022-03-19 良姜

    学习了

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authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Feb 07 18:42:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821190, encodeId=e2a81821190a0, content=<a href='/topic/show?id=002b10135947' target=_blank style='color:#2F92EE;'>#首次证实#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101359, encryptionId=002b10135947, topicName=首次证实)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Oct 28 01:42:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887983, encodeId=ccfe188e98387, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
    2019-06-01 维他命
  4. 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03:42:00 CST 2019, time=2019-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961384, encodeId=d92d196138449, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jun 01 20:42:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896449, encodeId=77e21896449a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Thu Feb 07 18:42:00 CST 2019, time=2019-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1821190, encodeId=e2a81821190a0, content=<a href='/topic/show?id=002b10135947' target=_blank style='color:#2F92EE;'>#首次证实#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101359, encryptionId=002b10135947, topicName=首次证实)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/pSGl6CJeZ2PzWxdhCtrvv4U9Q281RV8e0AKmlB5ib93DibbiaRyOzmkCdz5F04cbfX5RGOpG4dOXvuQW1fumibVeBg/132, createdBy=fc342500110, createdName=ms9833124466084992, createdTime=Mon Oct 28 01:42:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887983, encodeId=ccfe188e98387, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
    2019-02-07 一闲
  5. [GetPortalCommentsPageByObjectIdResponse(id=1203989, encodeId=e8d51203989d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210601/7bc23eec272e4164811f9db8c32bd6d0/224de44e1ed644e5b3a11a9ae2d4e078.jpg, createdBy=9d1c5453900, createdName=良姜, createdTime=Sat Mar 19 10:19:40 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871107, encodeId=81eb18e11071c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Dec 10 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style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1203989, encodeId=e8d51203989d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210601/7bc23eec272e4164811f9db8c32bd6d0/224de44e1ed644e5b3a11a9ae2d4e078.jpg, createdBy=9d1c5453900, createdName=良姜, createdTime=Sat Mar 19 10:19:40 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871107, encodeId=81eb18e11071c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Dec 10 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style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
    2019-08-16 guojianrong
  7. [GetPortalCommentsPageByObjectIdResponse(id=1203989, encodeId=e8d51203989d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210601/7bc23eec272e4164811f9db8c32bd6d0/224de44e1ed644e5b3a11a9ae2d4e078.jpg, createdBy=9d1c5453900, createdName=良姜, createdTime=Sat Mar 19 10:19:40 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871107, encodeId=81eb18e11071c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Dec 10 03:42:00 CST 2019, time=2019-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961384, encodeId=d92d196138449, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jun 01 20:42:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896449, encodeId=77e21896449a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, 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style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1203989, encodeId=e8d51203989d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210601/7bc23eec272e4164811f9db8c32bd6d0/224de44e1ed644e5b3a11a9ae2d4e078.jpg, createdBy=9d1c5453900, createdName=良姜, createdTime=Sat Mar 19 10:19:40 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871107, encodeId=81eb18e11071c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Dec 10 03:42:00 CST 2019, time=2019-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961384, encodeId=d92d196138449, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jun 01 20:42:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896449, encodeId=77e21896449a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, 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style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), 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topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=1203989, encodeId=e8d51203989d8, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210601/7bc23eec272e4164811f9db8c32bd6d0/224de44e1ed644e5b3a11a9ae2d4e078.jpg, createdBy=9d1c5453900, createdName=良姜, createdTime=Sat Mar 19 10:19:40 CST 2022, time=2022-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871107, encodeId=81eb18e11071c, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Tue Dec 10 03:42:00 CST 2019, time=2019-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961384, encodeId=d92d196138449, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jun 01 20:42:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896449, encodeId=77e21896449a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, 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style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Fri Aug 16 04:42:00 CST 2019, time=2019-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987916, encodeId=8f3e198e91610, content=<a href='/topic/show?id=b08385696e5' target=_blank style='color:#2F92EE;'>#腹部脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85696, encryptionId=b08385696e5, topicName=腹部脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Mon Jul 01 22:42:00 CST 2019, time=2019-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809584, encodeId=29cf180958427, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Mon Aug 12 23:42:00 CST 2019, time=2019-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046576, encodeId=f9d820465e6d4, content=<a href='/topic/show?id=6707e7845b4' target=_blank style='color:#2F92EE;'>#细胞因子IL-6#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77845, encryptionId=6707e7845b4, topicName=细胞因子IL-6)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6c3a189, createdName=longqijun248, createdTime=Wed Feb 27 03:42:00 CST 2019, time=2019-02-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=362641, encodeId=5e8b36264118, content=骑自行车有益于身心健康。, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu Mar 14 19:44:49 CST 2019, time=2019-03-14, status=1, ipAttribution=)]
  10. 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03:42:00 CST 2019, time=2019-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961384, encodeId=d92d196138449, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Jun 01 20:42:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896449, encodeId=77e21896449a9, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, 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    2019-03-14 jyzxjiangqin

    骑自行车有益于身心健康。

    0