盘点:Diabetes Care 8月原始重要研究汇总

2018-08-31 MedSci MedSci原创

333

【1】考虑患者性别、BMI等,糖尿病诊治效果会更好

https://doi.org/10.2337/dc18-0344


近日,一项来自Exeter大学医学院的研究结果显示,医生在对糖尿病患者进行诊断时,如果考虑性别、BMI等,能够提高诊断治疗的效果,同时能够避免副作用的发生。在这项研究中,作者发现基于患者的性别以及BMI,能够提高医生对额外药物的选择准确度,在提高治疗效果的同时能够降低副作用的发生风险。例如肥胖女性群体使用thiazolidinediones降血糖的效果明显优于sulfonylureas。而非肥胖的男性则是相反的结果。此外,该研究还发现需要共享患者的信息,才能有助于提高每一位患者的治疗效果。

【2】非肺脏累及的肺外结节病临床特点分析

https://doi.org/10.1016/j.chest.2018.02.003

近日,来自英国曼彻斯特大学的研究人员利用UK Biobank中50多万人的数据开展了一项研究,其中包括各约2.4万名的2型糖尿病及冠心病患者以及4.5万多名癌症患者。结果发现,在冠心病及癌症患者中均没有出现所谓的肥胖悖论,但在2型糖尿病患者中却的确有这一现象,稍微胖一点的2型糖尿病患者反而比正常体重的要健康一些。


【3】老年妇女骨更新的生化标志物与糖尿病风险

https://doi.org/10.2337/dc18-0849

近日,新的一项研究调查了老年妇女骨钙素(骨骼形成标志物)和I型胶原蛋白C-端肽(CTX,骨吸收标志物)与糖尿病之间的关系。包含了来自以人群为基础的心血管健康研究中的1455名女性参与者。研究人员使用多元线性回归评估了血清总OC和CTX水平与胰岛素抵抗(HOMA-IR)之间的横截面关联,并使用多变量Cox比例风险模型评估了这两种标志物与糖尿病之间的纵向关联,糖尿病由随访期间的葡萄糖测量、降糖药物和ICD-9代码来定义。结果发现,OC与CTX密切相关。在横断面分析中,调整人口统计学指标、生活方式和临床协变量后,可观察到OC和CTX与HOMA-IR之间具有显著或接近显著的负相关。在11.5年的中位随访期间,共出现了196例糖尿病病例。由此可见,在绝经后期女性中,较低的OC和CTX水平与基线胰岛素抵抗的风险增加相关,并且关联程度相似,并且与长期随访中糖尿病发生有关。进一步研究描述异常骨稳态和能量代谢之间相关性的机制可能揭示预防这些与年龄相关的疾病的新方法。

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    2018-09-01 liumin1987

    嗯嗯,学习了。

    0

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    2018-09-01 医者仁心5538

    学习了

    0

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    2018-09-01 明月清辉

    谢谢分享,学习了

    0

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    2018-09-01 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2018-09-01 飛歌

    学习了很不错

    0