Neurology:创伤性脑损伤后死亡率以及创伤后癫痫对其影响

2018-08-03 xing.T MedSci原创

由此可见,该研究的结果表明PTE患者的长期死亡率高于其他TBI患者,尽管这种差异的原因尚不清楚。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估创伤后癫痫(PTE)对创伤性脑损伤(TBI)后死亡率和死亡原因的影响。

研究人员回顾性地收集1996年至2013年间持续TBI患者的医疗报告。确定PTE患者后并为每位PTE患者挑选2个非PTE匹配的TBI对照者,该数据库包括714名患者。研究人员收集了受试者的人口统计学数据、损伤的原因和机制、损伤的性质(局灶性损伤、颅内出血)、从事故到首次癫痫发作的时间、缓解率、进行的神经外科手术和死亡率数据。

714例患者中男性为555例(77.7%),女性为159例(22.3%)。与对照TBI患者相比,PTE患者的长期死亡率明显增加。受伤后约1年,这种增加变得明显,当时大约95%的非PTE和PTE患者都存活; 之后,死亡率的差异有所增加。这种差异在伤后至少长达15年仍然显著,当时大约65%的伴有TBI的非PTE患者存活,而仅有45%的PTE患者存活。在PTE患者中,死亡率增加1.75倍(p=0.0001)。死亡原因没有显著差异。

由此可见,该研究的结果表明PTE患者的长期死亡率高于其他TBI患者,尽管这种差异的原因尚不清楚。

原始出处:

Jessina Uski,et al. Mortality after traumatic brain injury and the effect of posttraumatic epilepsy.neurology.2018. http://n.neurology.org/content/early/2018/08/01/WNL.0000000000006077

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    2018-12-19 amyloid
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    2018-10-01 yinhl1978
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    2018-08-11 wanghx2006

    学习

    0

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