Kyowa Hakko Kirin公布其白细胞介素-17受体A单抗brodalumab治疗轴性脊柱关节炎患者的临床3期阳性结果

2019-06-18 不详 MedSci原创

在2019年欧洲风湿病学年会,日本Kyowa Hakko Kirin公司公布其抗白细胞介素-17(IL-17)受体A单抗brodalumab(KHK4827),对轴性脊柱关节炎(axSpA),包括强直性脊柱炎(AS)和非放射性轴性脊柱关节炎(nr-axSpA),为期16周的疗效和安全性结果。

在2019年欧洲风湿病学年会,日本Kyowa Hakko Kirin公司公布其抗白细胞介素-17(IL-17)受体A单抗brodalumab(KHK4827),对轴性脊柱关节炎(axSpA),包括强直性脊柱炎(AS)和非放射性轴性脊柱关节炎(nr-axSpA),为期16周的疗效和安全性结果。

研究结果显示brodalumab疗效明显高于安慰剂组,且安全性与安慰剂组之间没有明显差异。

这些结果表明,brodalumab在16周内耐受良好,对axSpA的治疗有效。

基于上述结果,Kyowa Hakko Kirin计划提交brodalumab的补充应用,以增加治疗axSpA的新适应症。

Brodalumab是一种完全人类抗白细胞介素-17(IL-17)受体A抗体,可抑制IL-17A、IL-17F和其他IL-17的生物活性。Brodalumab于2016年7月在日本被批准用于对现有疗法反应不足的牛皮癣(寻常型银屑病,银屑病性关节炎,脓疱型牛皮癣和银屑病性红皮病)治疗。

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    2020-04-27 snf701207
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    2019-06-20 lmm397
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    2019-06-20 zxl733
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