PLoS One:偏头痛会降低抑郁症状缓解率

2015-05-25 MedSci MedSci原创

偏头痛是临床最常见的原发性头痛类型,临床以发作性中重度、搏动样头痛为主要表现,头痛多为偏侧,一般持续4~72小时,可伴有恶心、呕吐,光、声刺激或日常活动均可加重头痛,安静环境、休息可缓解头痛。目前还没有关于偏头痛对重度抑郁症(MDD)患者的抑郁、焦虑和躯体症状影响,以及随访两年后偏头痛对其抑郁症症状缓解情况的影响的研究,Hung CI等研究者进行的一项研究便是为了探究以上问题。该研究纳入了去精神科


偏头痛是临床最常见的原发性头痛类型,临床以发作性中重度、搏动样头痛为主要表现,头痛多为偏侧,一般持续4~72小时,可伴有恶心、呕吐,光、声刺激或日常活动均可加重头痛,安静环境、休息可缓解头痛。

目前还没有关于偏头痛对重度抑郁症(MDD)患者的抑郁、焦虑和躯体症状影响,以及随访两年后偏头痛对其抑郁症症状缓解情况的影响的研究,Hung CI等研究者进行的一项研究便是为了探究以上问题。

该研究纳入了去精神科门诊的重度抑郁症(MDD)患者共106人,并且从纳入之日算起,对其随访2年。研究期间使用了汉密尔顿抑郁评定量表、医院焦虑抑郁量表和躯体症状量表。根据第二版国际头痛疾病分类标准对偏头痛进行诊断。研究者根据偏头痛情况将参与者分为三组:无偏头痛、非活动性偏头痛、活动性偏头痛。通过多因素逻辑回归分析充分缓解抑郁症相关的重要因素。

研究结果显示,随访未经药物治疗的病人发现,活动性偏头痛组比没有偏头痛组具有明显的更严重的焦虑和躯体症状,同时活动性偏头痛组其随访2年后抑郁症缓解情况也最差,症状充分缓解所占百分比最低。对于非活动性偏头痛与没有偏头痛的组比较,并没有发现两组在抑郁、焦虑和躯体症状有任何显著性差异存在。随访期间活动性头痛是降低抑郁症状充分缓解比例的明显的因素。

研究结果表明,随访期间活动性头痛会导致重度抑郁症(MDD)患者其2年后抑郁、焦虑和躯体症状等的充分缓解率的显著降低,并且活动性偏头痛患者其随访期间焦虑和躯体症状缓解情况也更差。因此研究者提出对于伴有偏头痛的重度抑郁症(MDD)患者,应该将抑郁症和偏头痛纳入治疗计划,同时进行治疗。

原始出处:


Hung CI, Liu CY, Yang CH, Wang SJ: The Impacts of Migraine among Outpatients with Major Depressive Disorder at a Two-Year Follow-Up. PLoS One 2015, 10(5):e0128087.

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    2015-07-07 保守主义

    有点启发

    0

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    2015-07-07 保守主义

    想到问题了

    0

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    2015-05-31 huaxipanxing

    看看

    0

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    2015-05-26 lovetcm

    这个研究非常有意思,也反映了不同的症状之间相互的拮抗,未来应该在更多的疾病中发起类似的研究

    0

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