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张志英：骨髓神经组织定向干细胞的来源、分离、培养及在周围神经的应用

2015-09-28 佚名 生物谷

骨髓组织干细胞
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在2014（第六届）干细胞技术临床应用论坛上，张教授就“骨髓神经组织定向干细胞的来源、分离、培养及在周围神经的应用”做了精彩报告。 张志英，博士，硕士生导师，副教授，现工作于第二军医大学解剖学教研室暨生物医学工程研究所暨再生医学研究中心，主要从事脊髓损伤及周围神经再生修复的干细胞治疗等研究。张教授的演讲视频已上传至行云学院供交流学习。 骨髓内除造血干细胞及基质干细胞外，另有极小胚胎干细胞


在2014（第六届）干细胞技术临床应用论坛上，张教授就“骨髓神经组织定向干细胞的来源、分离、培养及在周围神经的应用”做了精彩报告。

张志英，博士，硕士生导师，副教授，现工作于第二军医大学解剖学教研室暨生物医学工程研究所暨再生医学研究中心，主要从事脊髓损伤及周围神经再生修复的干细胞治疗等研究。张教授的演讲视频已上传至行云学院供交流学习。

骨髓内除造血干细胞及基质干细胞外，另有极小胚胎干细胞（very small embryonic-like stem cells，VSEL)、多潜能干细胞（multipotential adult progenitor cells ，MAPC)， 以及CXCR4 阳性的组织定向干细胞（tissue-committed stem cells，TCSCs）包括骨骼肌、心、肝及神经组织定向干细胞（neural tissue-committed stem cells，NTCSCs）等的报道，骨髓基质干细胞是一类异质性干细胞， 并具有多向分化的潜能， VSCL、MAPC、TCSCs、NTCSCs 等是骨髓基质干细胞内的亚细胞群还是独立的细胞群？

有关这个问题目前仍有争议，目前的研究是否为从不同的角度研究着同一类细胞？张教授及所在团队通过先贴壁、后悬浮的方法从骨髓中分离、培养了神经组织定向干细胞，并通过免疫组织化学、流式细胞仪、电镜、PCR 等方法对其进行了鉴定。同时应用骨髓源性神经组织定向干细胞或其分化的神经元移植或构建组织工程神经修复大鼠、兔及犬的长段坐骨神经缺损，探讨其修复神经功能的作用及机制。

观看张教授的演讲视频→http://xy.bioon.com/course_video/zhang-zhi-ying-gu-sui-shen-jing-zu-zhi-ding699300.html

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1768991, encodeId=71351e68991e7, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Fri Jul 15 03:23:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748237, encodeId=028d1e482371c, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Mon Apr 25 14:23:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37539, encodeId=c8dd3e5399d, content=点个赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Mon Sep 28 23:56:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37525, encodeId=0e0b3e52535, content=很是精彩，非常精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Mon Sep 28 11:58:00 CST 2015, time=2015-09-28, status=1, ipAttribution=)]
    2016-07-15 liao1632

    #定向#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1768991, encodeId=71351e68991e7, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Fri Jul 15 03:23:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748237, encodeId=028d1e482371c, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Mon Apr 25 14:23:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37539, encodeId=c8dd3e5399d, content=点个赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Mon Sep 28 23:56:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37525, encodeId=0e0b3e52535, content=很是精彩，非常精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Mon Sep 28 11:58:00 CST 2015, time=2015-09-28, status=1, ipAttribution=)]
    2016-04-25 Smile2692

    #周围神经#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1768991, encodeId=71351e68991e7, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Fri Jul 15 03:23:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748237, encodeId=028d1e482371c, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Mon Apr 25 14:23:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37539, encodeId=c8dd3e5399d, content=点个赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Mon Sep 28 23:56:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37525, encodeId=0e0b3e52535, content=很是精彩，非常精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Mon Sep 28 11:58:00 CST 2015, time=2015-09-28, status=1, ipAttribution=)]
    2015-09-28 lecoo

    点个赞

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1768991, encodeId=71351e68991e7, content=<a href='/topic/show?id=d7674593e05' target=_blank style='color:#2F92EE;'>#定向#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45937, encryptionId=d7674593e05, topicName=定向)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920637977772, createdName=liao1632, createdTime=Fri Jul 15 03:23:00 CST 2016, time=2016-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748237, encodeId=028d1e482371c, content=<a href='/topic/show?id=15b33952464' target=_blank style='color:#2F92EE;'>#周围神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39524, encryptionId=15b33952464, topicName=周围神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f00136108751, createdName=Smile2692, createdTime=Mon Apr 25 14:23:00 CST 2016, time=2016-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37539, encodeId=c8dd3e5399d, content=点个赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1ab1619415, createdName=lecoo, createdTime=Mon Sep 28 23:56:00 CST 2015, time=2015-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=37525, encodeId=0e0b3e52535, content=很是精彩，非常精彩, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1a01625167, createdName=zhouxue1990, createdTime=Mon Sep 28 11:58:00 CST 2015, time=2015-09-28, status=1, ipAttribution=)]
    2015-09-28 zhouxue1990

    很是精彩，非常精彩

    0