Circulation:急性冠脉综合征女性患者的住院死亡率明显高于男性患者!

2019-04-15 MedSci MedSci原创

冠心病是女性死亡的主要原因。急性冠状动脉综合征(ACS)是冠心病的一种急性表现,目前我国仍缺乏对急性冠状动脉综合征(ACS)住院女性的护理质量和预后的系统评价。

冠心病是女性死亡的主要原因。急性冠状动脉综合征(ACS)是冠心病的一种急性表现,目前我国仍缺乏对急性冠状动脉综合征(ACS)住院女性的护理质量和预后的系统评价。

CCC-ACS(改善中国血管疾病的护理—急性冠状动脉综合征)计划是美国心脏协会和中国心脏病学会开展的全国性研究。利用CCC-ACS计划的数据,研究人员对2014-2018年中国192家医院收治的82196位ACS患者在急性管理、二级预防医学治疗和住院死亡率方面的性别差异进行评估。

ACS女性患者的年龄要大于男性患者(69.0 vs 61.1岁,p<0.001),并发症也多于男性。经过多变量校正后,符合条件的女性进行ASC急性治疗的可能性低于男性,包括早期双重抗血小板疗法、住院期间的肝素治疗和ST段抬高型心肌梗死的再灌注治疗。至于二级预防,符合条件的女性进行双重抗血小板治疗、血管紧张素转换酶抑制剂/血管紧张素受体阻滞剂、他汀类药物(出院后)、住院期间接受戒烟和心脏康复咨询的可能性较低。ACS女性患者的住院死亡率高于男性(2.60% vs 1.50%,P<0.001)。经临床特征和紧急治疗后,ST段抬高型心肌梗死患者和非ST段抬高型ACS的住院死亡率无性别差异。

在中国,女性ACS患者接受紧急治疗和二级预防治疗的比例远低于男性患者。住院死亡率的性别差异住院归因于较差的临床资料和提供给ACS女性的基于证据的紧急治疗较少。为了缩小ACS患者在护理质量和治疗预后方面的性别差异,有必要开展有针对不同性别的护理和治疗策略研究。

原始出处:

Yongchen Hao,et al.Sex Differences in In-Hospital Management and Outcomes of Patients With Acute Coronary Syndrome.Circulation. Jan 22, 2019. https://doi.org/10.1161/CIRCULATIONAHA.118.037655

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