Nat Commun:戴眼镜的人似乎更聪明?超大型研究:确定了148个影响一般认知功能的基因位点

2018-06-02 佚名 中国生物技术网

一般而言,戴眼镜的人看上去会比较“有学问”,有学问自然就会聪明。真的是这样吗?近日,一项新的研究证实,戴眼镜的人或许还真的比视力正常的人聪明。近日发表在《Nature Communications》上的一项迄今为止最大型的认知功能遗传学研究揭示了智力与视力有显着联系。这项研究由来自世界各地的研究人员共同完成,包括澳大利亚、奥地利、克罗地亚、芬兰、法国、德国、荷兰、冰岛、爱尔兰、挪威、瑞典以及美国。

一般而言,戴眼镜的人看上去会比较“有学问”,有学问自然就会聪明。真的是这样吗?近日,一项新的研究证实,戴眼镜的人或许还真的比视力正常的人聪明。近日发表在《Nature Communications》上的一项迄今为止最大型的认知功能遗传学研究揭示了智力与视力有显着联系。这项研究由来自世界各地的研究人员共同完成,包括澳大利亚、奥地利、克罗地亚、芬兰、法国、德国、荷兰、冰岛、爱尔兰、挪威、瑞典以及美国。

研究团队分析了300486人的数据,这些人年龄分布在16至102岁之间,且参加了在澳大利亚、欧洲、北美等地区进行的57项队列研究。研究人员发现了148个与思维能力相关的基因,包括记忆、推理、心智处理速度以及空间意识等。其中58个基因在过去从未被报道过。他们认为这项研究的成果能够帮助人们理解某些疾病(比如痴呆症)发生时导致的认知功能衰退。

参与这些研究的受测者都接受了各种思维测试,测试结果被归纳为一个通用的认知能力分数。他们也都接受了基因检测,没有发现痴呆和中风患者。与那些得分较低的人相比,那些在认知测试中得分最高的人更有可能需要佩戴眼镜。

一些人的认知功能高于其他人。这些个体之间的差异从童年后期开始,在整个生命过程中会一直存在。具有较高认知功能的个体往往寿命更长。

该研究还显示,较高的认知能力与已知在良好心血管健康中起关键作用的基因之间存在关联。但遗憾的是,这项研究的设计意味着研究人员无法解释为什么一个人的智力、视力差和心血管健康之间会存在关联。

爱丁堡大学认知衰老和认知流行病学研究中心(CCACE)的Gail Davies教授主导了这项研究,他说:“这是关于认知功能的最大型的遗传学研究,确定了很多导致思维能力遗传可能性的基因差异。这项关于共同遗传效应对健康和大脑结构作用的发现为探索这些差异在一生中影响思维能力的机制提供了基础。”

除了拥有更好的思维能力,基因区域还与更好的心血管和心理健康、降低肺癌风险和更长的寿命相关。

CCACE的教授Ian Deary说:“大约十年前,我们招募了3000人研究与智力相关的基因,然而我们一无所获。现在,参与研究的受测人数是之前的100倍,有超过200名科学家共同合作,我们发现了与智力相关的将近150个基因区域。我们还需要更大型的研究才能了解到事情的全貌。目前,我们要更近一步分析这些研究结果,以确定其对于我们理解疾病和衰老导致的认知功能衰退有什么帮助。我们通过这些结果了解到的一件事是,良好的思维能力也是整体健康的一部分。”

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    2019-02-28 liuli5079
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    2018-10-10 liye789132251
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  4. 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  5. 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  6. 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target=_blank style='color:#2F92EE;'>#聪明#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80840, encryptionId=9d858084092, topicName=聪明)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=316420160942, createdName=Boyinsh, createdTime=Mon Jun 04 06:06:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320931, encodeId=10e332093139, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sat Jun 02 21:34:39 CST 2018, time=2018-06-02, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=320887, encodeId=3d6532088e2d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 02 17:43:14 CST 2018, time=2018-06-02, status=1, ipAttribution=)]
    2018-06-04 Boyinsh
  7. 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GetPortalCommentsPageByObjectIdResponse(id=320887, encodeId=3d6532088e2d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 02 17:43:14 CST 2018, time=2018-06-02, status=1, ipAttribution=)]
    2018-06-02 王秀

    学习了.涨知识了!

    0

  8. 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    2018-06-02 bapan0434

    在不断的学习中进步-谢谢分享!

    0

  9. 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    2018-06-02 131****1460

    学习了受益匪浅

    0

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target=_blank style='color:#2F92EE;'>#聪明#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80840, encryptionId=9d858084092, topicName=聪明)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=316420160942, createdName=Boyinsh, createdTime=Mon Jun 04 06:06:00 CST 2018, time=2018-06-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320931, encodeId=10e332093139, content=学习了.涨知识了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDM9swhbgTo7nzqRKzMmzckmEoeTyLQVDCgjqsicjyhxPs0vPoYU6GsSYbCjSkNHicJkz3NL0a0EbUMVdNjkctXI6FocpGKaVr9E/0, createdBy=29392048316, createdName=王秀, createdTime=Sat Jun 02 21:34:39 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320928, encodeId=776032092823, content=在不断的学习中进步-谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=35998606, createdName=bapan0434, createdTime=Sat Jun 02 21:05:38 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320904, encodeId=85b232090422, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Jun 02 19:51:52 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320887, encodeId=3d6532088e2d, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jun 02 17:43:14 CST 2018, time=2018-06-02, status=1, ipAttribution=)]
    2018-06-02 清风拂面

    谢谢分享学习

    0

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