TEDMED 2015:肥胖和压力可促使女孩的青春期提前

2015-11-24 MedSci MedSci原创

儿科内分泌学专家Louise Greenspan认为肥胖和压力是导致女孩青春期提前的两个主要因素,青春期发育提前带来身体和心理的影响。

儿科内分泌学专家Louise Greenspan认为肥胖和压力是导致女孩青春期提前的两个主要因素,青春期发育提前带来身体和心理的影响。

在TEDMED 2015会议上,Greenspan 博士报告较早达到青春期的女孩抑郁的风险较高,进展为饮食失调、滥用药物和初始性行为时间提前。

这些青春期提前的女孩在成年以后患乳腺癌和心脏病的风险也相对增加了。

青春期的平均年龄呈渐进式下降,最早可能开始于1980年代。

通常认为女孩8岁之前不应该开始乳房发育和阴毛生长。Greenspan博士报告现在的情况是有15%的女孩在7岁时就乳房已经开始发育。平均而言初次月经来潮发生在12岁。

各个种族和族裔群体中肥胖度越高的女孩面临的早熟风险越大(Pediatrics.2013;132:1019-1027)。研究发现黑人女孩乳房发育的平均年龄为8.75岁,西班牙裔女孩乳房发育的平均年龄为9.25岁,白人和亚洲女孩乳房发育的平均年龄为9.75岁。

身体脂肪产生雌激素,而雌激素通常是青春期卵巢释放的。女孩具有更多的身体脂肪意味着高水平的雌激素,从而导致乳房发育。

根据美国疾病控制预防中心的一份报告,在美国6-11岁的儿童过度肥胖的比例从1980年的7%增加到2012年的近18%。在同一时期,12-19岁的青少年肥胖比例从5%上升到接近21%。

压力高也是青春期提前的罪魁祸首

压力是性早熟的一个因素。其他风险因素是早期性虐待、家庭争吵和邻里间施暴。

最值得注意的是,不和父亲生活在一起的女孩相比较于和父亲生活在一起的女孩,在12岁以前初次月经来潮的概率增加了一倍。

Greenspan博士说这种现象的原因可能是单亲家庭需要面对更多的持续的低水平压力。进化理论的解释是身体可能试图让生育年龄提前,因为身体认为压力高的女孩会死的早。

而人们通常倾向于指责干扰内分泌的化学物质使青春期提前,这些化学物质通常存在于塑料和杀虫剂中。

这些化学物质可以模拟体内激素,而某些激素特别是雌激素是体内参与青春期调节的重要激素。但是从环境中清除干扰内分泌的化学物质几乎是不可能的,减少干扰内分泌的化学物质对青春期提前的影响并没有确凿的证据。

Greenspan博士总结,虽然担心这些干扰内分泌的化学物质的有害影响,一个更有效的公共卫生干预措施将是尝试减少肥胖症,并建立一些更大的社会基础设施以缓冲儿童受到的来自于贫困的压力。

原始出处:

Obesity and Stress May Push Girls' Puberty Earlier.Medscape.November 23,2015.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=101887, encodeId=6b9b10188e56, content=这些个评论。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Sun Aug 21 11:07:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702927, encodeId=30471e0292717, content=<a href='/topic/show?id=72351e25437' target=_blank style='color:#2F92EE;'>#TED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17254, encryptionId=72351e25437, topicName=TED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76e230462388, createdName=aliceclz, createdTime=Mon Mar 07 07:41:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51861, encodeId=14065186135, content=这个也有, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 19:22:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51862, encodeId=c91d51862dd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 19:22:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44154, encodeId=59c044154e0, content=心理社会模式, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77e41648823, createdName=miaotao, createdTime=Mon Nov 30 10:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275490, encodeId=2dee12e549047, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606730, encodeId=fbdb1606e3047, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629115, encodeId=16fe162911541, content=<a href='/topic/show?id=7a1a604538' target=_blank style='color:#2F92EE;'>#DME#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6045, encryptionId=7a1a604538, topicName=DME)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713521313796, createdName=徐岩, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-08-21 Mr.Li先生

    这些个评论。。。

    0

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    2016-03-07 aliceclz
  3. [GetPortalCommentsPageByObjectIdResponse(id=101887, encodeId=6b9b10188e56, content=这些个评论。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Sun Aug 21 11:07:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1702927, encodeId=30471e0292717, content=<a href='/topic/show?id=72351e25437' target=_blank style='color:#2F92EE;'>#TED#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17254, encryptionId=72351e25437, topicName=TED)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76e230462388, createdName=aliceclz, createdTime=Mon Mar 07 07:41:00 CST 2016, time=2016-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51861, encodeId=14065186135, content=这个也有, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 19:22:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51862, encodeId=c91d51862dd, content=好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fe261399236, createdName=xyfg98, createdTime=Mon Jan 04 19:22:00 CST 2016, time=2016-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44154, encodeId=59c044154e0, content=心理社会模式, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=77e41648823, createdName=miaotao, createdTime=Mon Nov 30 10:16:00 CST 2015, time=2015-11-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1275490, encodeId=2dee12e549047, content=<a href='/topic/show?id=5d0299032b9' target=_blank style='color:#2F92EE;'>#青春期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99032, encryptionId=5d0299032b9, topicName=青春期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4ba8129, createdName=zhzhxiang, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606730, encodeId=fbdb1606e3047, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629115, encodeId=16fe162911541, content=<a href='/topic/show?id=7a1a604538' target=_blank style='color:#2F92EE;'>#DME#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6045, encryptionId=7a1a604538, topicName=DME)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=713521313796, createdName=徐岩, createdTime=Thu Nov 26 14:41:00 CST 2015, time=2015-11-26, status=1, ipAttribution=)]
    2016-01-04 xyfg98

    这个也有

    0

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    2016-01-04 xyfg98

    好文章

    0

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    2015-11-30 miaotao

    心理社会模式

    0

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    2015-11-26 徐岩

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