J Gastroenterology:CT中发现冠状动脉斑块与患者肝脏脂肪变性之间的临床关系

2018-10-13 MedSci MedSci原创

非酒精性脂肪性肝病(NAFLD)在冠状动脉粥样硬化中起重要作用。受控衰减参数(CAP)的测量允许医生在早期和非侵入性地检测NAFLD。因此,研究人员评估了经CAP诊断的NAFLD与任何类型的冠状动脉斑块和不同斑块组成的存在相关关系。

背景
非酒精性脂肪性肝病(NAFLD)在冠状动脉粥样硬化中起重要作用。受控衰减参数(CAP)的测量允许医生在早期和非侵入性地检测NAFLD。因此,研究人员评估了经CAP诊断的NAFLD与任何类型的冠状动脉斑块和不同斑块组成的存在相关关系。

方法
研究人员进行了一项回顾性队列研究,所有的受试者在健康检查期间进行了肝脏纤维化CT扫描和冠状动脉扫描。

结果
研究人员发现相比于没有冠状动脉的患者,在存在冠状动脉斑块组中发现了更多具有CAP定义的NAFLD的受试者(61.3%VS73.5%,p= 0.005)。根据多变量回归模型, CAP≥222dB / m是与冠状动脉斑块存在相关的独立且显着的相关关系(OR 1.624,95%1.047-2.518,p= 0.030)。有趣的是,CAP≥222dB / m与非钙化斑块显着相关(OR 3.528,95%CI 1.463-8.511,p= 0.005),而在钙化斑块中则无显着差异(p= 0.171)。

结论
经CAP诊断NAFLD与冠状动脉斑块发生存在独立相关性,尤其是非钙化斑块。CAP可用于存在NAFLD可以患者的一级预防

原始出处:

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    2018-10-14 许安
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  6. 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504502, encodeId=a5b015045024a, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Mon Oct 15 05:10:00 CST 2018, time=2018-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1603644, encodeId=b9161603644b2, content=<a href='/topic/show?id=0018814e070' target=_blank style='color:#2F92EE;'>#肝脏脂肪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81470, encryptionId=0018814e070, topicName=肝脏脂肪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dee19073592, createdName=fengting9, createdTime=Mon Oct 15 05:10:00 CST 2018, time=2018-10-15, status=1, ipAttribution=)]
    2018-10-15 huangdf
  8. 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  9. 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