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ARCH PATHOL LAB MED：使用程序性死亡配体-1 (PD-L1)染色可从良性间皮反应中分离肉瘤样恶性间皮瘤？

2020-02-08 MedSci MedSci原创

肉瘤样恶性间皮瘤程序性死亡配体
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如何准确将良性和恶性间皮增生分离是一个困难的形态学问题。

如何准确将良性和恶性间皮增生分离是一个困难的形态学问题。本研究试图确定PD-L1染色是否能将间皮瘤与反应性间皮增生(RMPs)分离。我们使用抗PD-L1抗体22C3对2个组织微阵列进行了染色，研究共包含62个恶性间皮瘤和88个RMP。 同时，研究人员使用包含强度/分布的免疫反应评分对染色进行分级，分别为阴性，弱，中度和强度。由于PD-L1染色可能是异质的，所以我们还以组织性胸膜炎的形式对10个肉瘤/增生性间皮瘤（SMM）完整切片和梭形RMP的10个完整切片进行了染色，这是SMM的主要形态学差异。这20例均不在组织芯片上。

研究显示，RMPs在上皮样细胞或梭形细胞间室通常呈阴性，有时染色较弱，而14个SMMs中有10个呈中到强染色，但在48个上皮样间皮瘤(EMMs)中只有6个呈中到强染色。SMM染色与RMP染色差异有统计学意义(P < .001)， EMM染色与RMP染色差异无统计学意义(P < .001)。组织性胸膜炎全节段未见染色(N = 8)或染色较弱(N = 2)，而10个完整节段中有9个呈中/强染色，差异有统计学意义(P = .02)。RMP染色不存在“热点”，说明RMPs的非均匀染色并不是一个混杂物。

研究表明，当鉴别诊断为RMP时，使用抗体22C3的强弥漫性PD-L1染色支持SMM的诊断，但PD-L1染色对区分EMMs和RMPs没有帮助。

原始出处：

Fatemeh Derakhshan, MD; Diana Ionescu, MD; Use of Programmed Death Ligand-1 (PD-L1) Staining to Separate Sarcomatoid Malignant Mesotheliomas From Benign Mesothelial Reactions

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    2020-07-29 12498761m56暂无昵称

    #程序性死亡#

    0

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    2020-12-15 yilong5287551

    #恶性间皮瘤#

    0

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    2021-01-03 yb6560

    #Pathol#

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    2020-02-10 smartjoy

    #PD-L1#

    0

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    2020-02-10 1249884fm92暂无昵称

    #间皮瘤#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1803325, encodeId=f706180332549, content=<a href='/topic/show?id=9a70e52596e' target=_blank style='color:#2F92EE;'>#程序性死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75259, encryptionId=9a70e52596e, topicName=程序性死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b78f2500065, createdName=12498761m56暂无昵称, createdTime=Wed Jul 29 08:09:00 CST 2020, time=2020-07-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1668545, encodeId=3bf71668545db, content=<a href='/topic/show?id=5b0f5296033' target=_blank style='color:#2F92EE;'>#恶性间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52960, encryptionId=5b0f5296033, topicName=恶性间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1526340063, createdName=yilong5287551, createdTime=Tue Dec 15 07:09:00 CST 2020, time=2020-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1786316, encodeId=35ca1e86316c6, content=<a href='/topic/show?id=569f13e9045' target=_blank style='color:#2F92EE;'>#Pathol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13790, encryptionId=569f13e9045, topicName=Pathol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b65161, createdName=yb6560, createdTime=Sun Jan 03 08:09:00 CST 2021, time=2021-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255048, encodeId=e602125504874, content=<a href='/topic/show?id=be71139214f' target=_blank style='color:#2F92EE;'>#PD-L1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=16, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13921, encryptionId=be71139214f, topicName=PD-L1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e76f39, createdName=smartjoy, createdTime=Mon Feb 10 13:09:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1579813, encodeId=834315e9813a5, content=<a href='/topic/show?id=6db59e28738' target=_blank style='color:#2F92EE;'>#间皮瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97287, encryptionId=6db59e28738, topicName=间皮瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d61a16562641, createdName=1249884fm92暂无昵称, createdTime=Mon Feb 10 13:09:00 CST 2020, time=2020-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610226, encodeId=f84d161022674, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Feb 10 13:09:00 CST 2020, time=2020-02-10, status=1, ipAttribution=)]
    2020-02-10 ms3994565386320060

    #Med#

    0