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CLIN CANCER RES：胶质母细胞瘤患者血浆细胞外囊泡的临床意义

2019-01-21 MedSci MedSci原创

间质母细胞瘤细胞外囊泡临床意义
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胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤。寻找可以反映肿瘤状态的血液生物标志物对GBM患者的临床管理的很重要。细胞外囊泡在体液中的数量多，稳定并且有许多肿瘤相关蛋白和RNA，使其成为潜在的最佳生物标志物。CLIN CANCER RES近期发表了一篇文章，研究GBM患者血浆细胞外囊泡在治疗后的诊断和随访中的作用，以及是否可以作为预后工具。

胶质母细胞瘤（GBM）是最常见的原发性脑肿瘤。寻找可以反映肿瘤状态的血液生物标志物对GBM患者的临床管理的很重要。细胞外囊泡在体液中的数量多，稳定并且有许多肿瘤相关蛋白和RNA，使其成为潜在的最佳生物标志物。CLIN CANCER RES近期发表了一篇文章，研究GBM患者血浆细胞外囊泡在治疗后的诊断和随访中的作用，以及是否可以作为预后工具。

作者收集了健康对照人群（n = 33），GBM患者（n = 43）和患有不同中枢神经系统恶性肿瘤（n = 25）患者的血浆。通过超速离心分离细胞外囊泡，并通过透射电镜，浓度和纳米粒子示踪分析进行鉴定。作者还分析了GBM患者血浆细胞外囊泡浓度与临床病理特征的关系。研究结果表明，GBM释放异质性细胞外囊泡，且可在血浆中检测到。与健康对照，脑转移瘤和轴外脑肿瘤相比，GBM血浆细胞外囊泡浓度更高。手术后，血浆细胞外囊泡浓度显着下降。在携带GBM的小鼠中，血浆细胞外囊泡浓度也增加。蛋白质组学分析发现了GBM独特的特征。

文章最后认为，较高的血浆细胞外囊泡水平可能有助于GBM临床诊断：GBM切除术后的水平降低，复发时增加可能为肿瘤监测和治疗反应评估提供帮助。

原始出处：

Daniela Osti, Massimiliano Del Bene, et al. Clinical Significance of Extracellular Vesicles in Plasma from Glioblastoma Patients. CLIN CANCER RES. January 2019 doi: 10.1158/1078-0432.CCR-18-1941

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    2019-03-11 huperzia

    #母细胞瘤#

    0

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    2019-07-24 30397604

    #胶质母细胞#

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    2019-01-23 huangshifeng

    #浆细胞#

    0

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    2019-01-23 spoonycyy

    #细胞瘤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1772290, encodeId=40661e7229099, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Mar 11 04:33:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052897, encodeId=e0f3205289ec6, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jul 24 14:33:00 CST 2019, time=2019-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466618, encodeId=9d6b14666188d, content=<a href='/topic/show?id=8d3e65434d4' target=_blank style='color:#2F92EE;'>#浆细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65434, encryptionId=8d3e65434d4, topicName=浆细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=181c6846356, createdName=huangshifeng, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475959, encodeId=c94d14e5959d8, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493583, encodeId=0a8014935837d, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599844, encodeId=85bc1599844d4, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358827, encodeId=74c235882e1b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Jan 21 19:36:05 CST 2019, time=2019-01-21, status=1, ipAttribution=)]
    2019-01-23 bnjfx@129.com

    #细胞外囊泡#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1772290, encodeId=40661e7229099, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Mar 11 04:33:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052897, encodeId=e0f3205289ec6, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jul 24 14:33:00 CST 2019, time=2019-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466618, encodeId=9d6b14666188d, content=<a href='/topic/show?id=8d3e65434d4' target=_blank style='color:#2F92EE;'>#浆细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65434, encryptionId=8d3e65434d4, topicName=浆细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=181c6846356, createdName=huangshifeng, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475959, encodeId=c94d14e5959d8, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493583, encodeId=0a8014935837d, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599844, encodeId=85bc1599844d4, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358827, encodeId=74c235882e1b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Jan 21 19:36:05 CST 2019, time=2019-01-21, status=1, ipAttribution=)]
    2019-01-23 charl1234573

    #囊泡#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1772290, encodeId=40661e7229099, content=<a href='/topic/show?id=c38963544cc' target=_blank style='color:#2F92EE;'>#母细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63544, encryptionId=c38963544cc, topicName=母细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b07438375157, createdName=huperzia, createdTime=Mon Mar 11 04:33:00 CST 2019, time=2019-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2052897, encodeId=e0f3205289ec6, content=<a href='/topic/show?id=ae848406335' target=_blank style='color:#2F92EE;'>#胶质母细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84063, encryptionId=ae848406335, topicName=胶质母细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a691420, createdName=30397604, createdTime=Wed Jul 24 14:33:00 CST 2019, time=2019-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466618, encodeId=9d6b14666188d, content=<a href='/topic/show?id=8d3e65434d4' target=_blank style='color:#2F92EE;'>#浆细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65434, encryptionId=8d3e65434d4, topicName=浆细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=181c6846356, createdName=huangshifeng, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475959, encodeId=c94d14e5959d8, content=<a href='/topic/show?id=2bcee797732' target=_blank style='color:#2F92EE;'>#细胞瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77977, encryptionId=2bcee797732, topicName=细胞瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf5e7252474, createdName=spoonycyy, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493583, encodeId=0a8014935837d, content=<a href='/topic/show?id=36dfe7869dd' target=_blank style='color:#2F92EE;'>#细胞外囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77869, encryptionId=36dfe7869dd, topicName=细胞外囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e979073459, createdName=bnjfx@129.com, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1599844, encodeId=85bc1599844d4, content=<a href='/topic/show?id=be324039e31' target=_blank style='color:#2F92EE;'>#囊泡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40397, encryptionId=be324039e31, topicName=囊泡)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=86bc18759177, createdName=charl1234573, createdTime=Wed Jan 23 10:33:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=358827, encodeId=74c235882e1b, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Mon Jan 21 19:36:05 CST 2019, time=2019-01-21, status=1, ipAttribution=)]
    2019-01-21 一个字-牛

    学习了谢谢分享

    0