Eur Radiol:玩转DTI,探究轻度认知障碍患者尚存的高级功能与白质脑网络连接性的相关性

2017-07-23 shaosai MedSci原创

轻度认知障碍(mild cognitive impairment, MCI)是介于正常衰老和痴呆之间的一种中间状态,是一种认知障碍症候群。而MCI患者保留着不同的执行能力。研究人员旨在利用扩散张量成像(DTI)探究轻度认知功能障碍(MCI)患者在进行高级和低级活动时结构脑网络间的差异来反应白质连接功能的价值。

轻度认知障碍(mild cognitive impairment, MCI)是介于正常衰老和痴呆之间的一种中间状态,是一种认知障碍症候群。而MCI患者保留着不同的执行能力。研究人员旨在利用扩散张量成像(DTI)探究轻度认知功能障碍(MCI)患者在进行高级和低级活动时结构脑网络间的差异来反应白质连接功能的价值。

本研究为回顾性横断面研究,共纳入了128例来自于阿尔兹海默病神经影像原始数据库的患者。所有患者都被诊断为MCI并进行了DTI的扫描。利用活动能力评分将评分前15名患者作为高级执行能力组,将评分后16名患者作为低级执行能力组。基于感兴趣区(ROI)分析,首先构建脑网络,并计算图论参数。利用自动纤维示踪技术来比较各大白质纤维束的差异。

本研究结果为高级执行能力组的脑网络大小、密度和集聚系数要高于低级执行能力组。高级执行能力组双侧下纵束和上纵束的部分各向异性(FA)要高于低级执行能力组。

本研究表明,对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维. 这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。

原始出处:

Farrar DC, Mian AZ, Budson AE,et al. Retained executive abilities in mild cognitive impairment are associated with increased white matter network connectivity. Eur Radiol. 2017. DOI: 10.1007/s00330-017-4951-4

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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
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    2017-11-14 whlxd
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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-10-06 yaanren
  4. 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createdTime=Tue Nov 14 21:15:00 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814145, encodeId=bbe518141457f, content=<a href='/topic/show?id=555e9453390' target=_blank style='color:#2F92EE;'>#连接性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94533, encryptionId=555e9453390, topicName=连接性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Fri Oct 06 00:15:00 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740335, encodeId=c2e11e4033520, content=<a href='/topic/show?id=5c73850113b' target=_blank style='color:#2F92EE;'>#脑网络#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85011, encryptionId=5c73850113b, topicName=脑网络)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b0d34733187, createdName=ms7421025882867189, createdTime=Thu Aug 10 07:15:00 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837298, encodeId=f9ac183e29822, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed May 09 17:15:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225823, encodeId=352422582324, content=白质纤维,进一步学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sun Jul 23 17:36:17 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225351, encodeId=224922535170, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jul 23 09:28:28 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225340, encodeId=911b225340bd, content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
  5. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b0d34733187, createdName=ms7421025882867189, createdTime=Thu Aug 10 07:15:00 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837298, encodeId=f9ac183e29822, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed May 09 17:15:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225823, encodeId=352422582324, content=白质纤维,进一步学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Mon Jul 24 14:08:05 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225674, encodeId=b3bd2256e44a, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 24 07:55:01 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225516, encodeId=20d1225516e9, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, 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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
  6. 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attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b0d34733187, createdName=ms7421025882867189, createdTime=Thu Aug 10 07:15:00 CST 2017, time=2017-08-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1837298, encodeId=f9ac183e29822, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Wed May 09 17:15:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225823, encodeId=352422582324, content=白质纤维,进一步学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/1103841572/C3426ED027FF661B0C576A5B3127C2E8/40, createdBy=39dc1706090, createdName=QQ25ed180f, createdTime=Mon Jul 24 14:08:05 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225674, encodeId=b3bd2256e44a, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 24 07:55:01 CST 2017, time=2017-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225516, encodeId=20d1225516e9, content=好好学习,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sun Jul 23 17:36:17 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225351, encodeId=224922535170, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jul 23 09:28:28 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225340, encodeId=911b225340bd, content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-24 QQ25ed180f

    白质纤维,进一步学习了。

    0

  7. 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createdTime=Tue Nov 14 21:15:00 CST 2017, time=2017-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1814145, encodeId=bbe518141457f, content=<a href='/topic/show?id=555e9453390' target=_blank style='color:#2F92EE;'>#连接性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94533, encryptionId=555e9453390, topicName=连接性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Fri Oct 06 00:15:00 CST 2017, time=2017-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1740335, encodeId=c2e11e4033520, content=<a href='/topic/show?id=5c73850113b' target=_blank style='color:#2F92EE;'>#脑网络#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85011, encryptionId=5c73850113b, topicName=脑网络)], 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Sun Jul 23 17:36:17 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225351, encodeId=224922535170, content=不错的,学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sun Jul 23 09:28:28 CST 2017, time=2017-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=225340, encodeId=911b225340bd, content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-24 大爰

    学习并分享!!

    0

  8. 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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-23 shaosai

    好好学习,涨知识

    0

  9. 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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-23 中医痴

    不错的,学习了,谢谢分享!

    0

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content=对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun Jul 23 09:19:48 CST 2017, time=2017-07-23, status=1, ipAttribution=)]
    2017-07-23 有备才能无患

    对于高级执行能力组脑网络的测量说明其具有更完整的白质纤维.这表明白质储备对执行能力具有保护能力。当失去这一储备时会导致阿尔兹海默病痴呆程度进展。

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