J Rheumatol:老年强直性脊柱炎患者膝关节和髋关节置换术发生率升高

2018-07-09 xiangting MedSci原创

近年来,老年AS患者THA的发生率翻了一番,超过了一般人群的增长。老年AS患者的TKA率也明显较高。

这项研究旨在探讨老年强直性脊柱炎(AS)患者初次全髋关节置换术(THA)和全膝关节置换术(TKA)的风险。

研究人员使用1999年至2013年美国医疗保险受益人行政数据来查找AS患者(<75岁)和非AS对照组。计算每组初次THA和TKA比率,并对年龄、性别和种族进行标准化。研究人员还通过THA状态分析了AS患者初次TKA的风险。

共分析了52,568例AS患者和4,617,179例无AS患者。1999年至2013年间,AS患者初次THA的标准化发生率从每1000患者年(PY)4.5翻番至每1000 PY 9.6。所有年份中,AS患者初次TKA的发生率均高于对照。2013年,AS患者中初次TKA的标准化发生率为每1000 PY 12.3,而对照组为5.7/1000PY(RR 2.14,95%CI 1.93-2.38)。进行了THA的AS患者初次TKA的发生率是无THA患者的两倍(20.4 vs 10.2/1000PY)。

近年来,老年AS患者THA的发生率翻了一番,超过了一般人群的增长。老年AS患者的TKA率也明显较高。AS患者中TKA风险升高可能是膝关节炎症损伤,或髋关节炎引起的下肢生物力学改变的结果。

原始出处:

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    2018-11-06 zywlvao
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    2019-04-09 yxch48
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