Heart:已知和新型房颤危险因素的性别差异

2018-09-03 xing.T MedSci原创

由此可见,较高的BMI是男性房颤较强的危险因素,而NT-pro-BNP、尿酸和胱抑素-C升高与女性房颤风险更密切。

房颤是女性血管疾病的危险因素,而且相比于男性风险更大。近日,心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员评估了43种已知和新型危险因素的效应以及房颤风险是否存在性别差异。

该研究的数据来自苏格兰心脏健康扩展队列,这是一项前瞻性队列研究,研究人员对房颤发病率进行了20多年的随访。Cox回归模型用于获得调整后的性别特异性HR和95%CIs,以及与个人特征、吸烟、身体指标、糖尿病、脂质、炎症、心脏和饮食和肾脏标志物相关的房颤女性与男性的HR比值(RHR)。

该研究共纳入了15737名参与者(52%为女性)。体重指数(BMI)、NT-pro-BNP、尿酸和胱抑素-C增加1个SD与房颤风险之间存在性别差异。对于BMI,女性的HR为1.17(95%CI为1.08-1.27),男性为1.36(95%CI为1.24-1.49)(RHR为0.86,95%CI为0.77-0.97); 对于NT-pro-BNP,女性为1.84(95%CI为1.62至2.09),男性为1.54(95%CI 为1.40-1.68)(RHR为1.22,95%CI为1.05-1.42);对于尿酸,女性为1.27(95%CI为1.14-1.41),男性为1.10(95%CI为1.00-1.20)(RHR为1.17,95%CI为1.01-1.35);对于胱抑素C,女性为1.22(95%CI为1.13-1.32),男性为1.07(95%CI为0.96-1.18)(RHR为1.16,95%CI为1.05-1.27)。

由此可见,较高的BMI是男性房颤较强的危险因素,而NT-pro-BNP、尿酸和胱抑素-C升高与女性房颤风险更密切。

原始出处:

Sanne A E Peters.et al. Established and novel risk factors for atrial fibrillation in women compared with men.Heart. 2018. http://dx.doi.org/10.1136/heartjnl-2018-313630

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    2018-09-04 zhaojie88
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    2018-09-04 slcumt
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    2018-09-04 liumin1987

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    2018-09-03 青龙偃月

    优质资源,共同学习

    0

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    2018-09-03 青龙偃月

    优质资源,共同学习

    0

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    2018-09-03 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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    2018-09-03 明月清辉

    谢谢谢分享,学习了

    0

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